HIV and ID Observations

November 28th, 2011

Tenofovir Gel Disappointing in VOICE Trial

From the Microbicide Trials Network: VOICE, an HIV prevention trial that has been evaluating two antiretroviral (ARV)-based approaches for preventing the sexual transmission of HIV in women – daily use of one of two different ARV tablets or of a vaginal gel – will be dropping the vaginal gel from the study … The DSMB recommended […]

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June 4th, 2011

HIV Epidemiology and Something Even Many Smart Medical Students Don’t Know

Periodically I like to give an informal quiz to the medical students about HIV epidemiology. It’s a multiple choice question that goes something like this: Based on the recent epidemiology of HIV in the United States, in what group are new cases of HIV infection rising the fastest? Men who have sex with men (MSM) Injection drug […]

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May 12th, 2011

HPTN 052 Results — Another Win for Early HIV Therapy

The results of the HPTN Study 052 — which randomized 1,763 serodiscordant couples to early vs delayed ART to evaluate whether this reduced the risk of HIV transmission — have just been released: Findings from the study were reviewed by an independent Data and Safety Monitoring Board (DSMB) …The DSMB concluded that initiation of ART by HIV-infected […]

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January 28th, 2011

Wow, That Was Fast: PrEP Guidelines Appear

With the ink barely dry on iPrEx — still tricky to type — along come “interim” guidelines from the CDC on pre-exposure prophylaxis (PrEP). Based on the results [iPrEx], CDC and other U.S. Public Health Service (PHS) agencies have begun to develop PHS guidelines on the use of PrEP for MSM at high risk for HIV […]

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July 30th, 2010

Perinatal Transmission of HIV “Solved” — Now How Do We Pay For It?

Conspicuously absent from this year’s International AIDS Conference were major studies on prevention of maternal-to-child transmission. It could be that I just missed them, so I emailed a colleague who specializes in the area, and she concurred: Nope, did not see or hear major PMTCT updates at IAS. The thing is, this problem has been all but solved, […]

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May 27th, 2010

HIV Treatment is Prevention!

The Lancet has just published a large prospective study demonstrating the protective effect of HIV treatment on the risk of viral transmission: 3381 couples were eligible for analysis … Only one of 103 genetically-linked HIV-1 transmissions was from an infected participant who had started ART, corresponding to transmission rates of 0·37 (95% CI 0·09—2·04) per 100 person-years […]

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April 4th, 2010

San Francisco Public Health: Treatment Recommended for All with HIV

Could there be anything more interesting than the start of the baseball season? Maybe, because this is quite something: In a major shift of HIV treatment policy, San Francisco public health doctors have begun to advise patients to start taking antiviral medicines as soon as they are found to be infected, rather than waiting — sometimes years — […]

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February 2nd, 2010

Bats in the Bedroom: Canadians Make a Policy Change

ID doctors know all too well the panicky call — usually from a terrified friend, family member, or colleague, or possibly the emergency room or primary care doc — about finding a bat in the house. Usually in the bedroom. (In one memorable case, it was the house cat’s leaping in the air to try and catch […]

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October 20th, 2009

Well That Was Fast! HIV Vaccine Trial Published

Remember the HIV vaccine trial press release?  The one announcing the first-ever positive result? Then the backlash, with people questioning how the analyses were done, and reported? Now, less than a month later, we have the scientific presentation and the paper appear on the same day. Read all about it here and here. If you want the view […]

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March 25th, 2009

March (Guideline) Madness …

A couple of interesting ID guidelines out this week.  For those of you too busy with basketball, here are the relevant links: Guidance for Control of Infections with Carbapenem-Resistant or Carbapenemase-Producing Enterobacteriaceae in Acute Care Facilities. Identified in 24 states and now found “routinely” in New York and New Jersey, these carbapenem-resistant Enterobacteriaceae (“CPE” is much […]

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