HIV and ID Observations

February 15th, 2021

Time to Fix the HIV Testing Algorithm — and Here’s How to Do It

Remember the revised HIV testing algorithm that debuted in 2014? The one that was supposed to solve all our problems? First, it included a “highly sensitive” screening test that started with a “4th Generation” combination antibody/antigen test. This decreased the window period between acquiring HIV and having a positive test, thanks to the antigen. Great! (These “generation” […]

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February 7th, 2021

Does Taking Vitamin D Prevent or Treat COVID-19?

Vitamin D supplementation — critical in prevention and treatment of COVID-19? Or does it do nothing — except further enrich the vitamin and supplements industry, which is worth more than 100 billion dollars? The challenge is figuring out which of these is the truth, and after several weeks of thinking about the issue, I find it’s far […]

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January 31st, 2021

Are We Expecting Too Much from Our COVID-19 Vaccines?

There are no absolutes in life. And nothing is perfect. Tom Brady isn’t always in the Super Bowl (hard to believe). Serena Williams occasionally exits tennis tournaments in the early rounds. Tom Hanks and Meryl Streep sometimes appear in movies that are stinkers. I’ve always thought that Frank Lloyd Wright’s Guggenheim Museum in New York fits horribly […]

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January 24th, 2021

John Bartlett and Hank Aaron — Consistently Great for a Long, Long Time

Early last week, we lost one of the true giants in Infectious Diseases, Dr. John Bartlett. Long-time Chief of ID at Johns Hopkins, he was a true Infectious Diseases polymath — deeply knowledgeable about such a wide range of topics that virtually everyone in our field knew and respected him. If you’ll permit me to lift […]

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January 18th, 2021

COVID-19 Vaccine Frequently Asked Questions

In case you missed it, over on the New England Journal of Medicine, we now have a list of Covid-19 Frequently Asked Questions. (Why this NEJM Journal Watch site and the actual New England Journal of Medicine use different capitalization rules for this disease is a mystery. And don’t get me started on the Washington Post, […]

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January 11th, 2021

After Ivermectin Controversy, A COVID-19-Free ID Link-o-Rama

Wow, quite the week for this country of ours. We’re all deeply saddened by the events, very hopeful that the transition in leadership will be peaceful. And also an eventful week for this little blog. When I wrote “Enter ivermectin — and let the controversy begin,” little did I know. Amazingly, this is already the second-most widely […]

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January 4th, 2021

Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux?

It’s an indisputable fact that we need better treatments for COVID-19. This is particularly true in the outpatient setting. Let’s count how many we have today, hmm, this shouldn’t take long. That would be zero — the same number we had over a year ago, when the disease first emerged in China. Something safe, easy to take […]

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December 20th, 2020

With Vaccine Rollout, a Mixture of Gratitude, Envy, and Cautious Hope

I. Gratitude Did I think we’d have two vaccines for COVID-19 available for distribution before 2021? Two vaccines with 95% efficacy in preventing disease, and nearly 100% in preventing severe disease? Vaccines that work across different patient populations, including the most vulnerable — especially older people? Not a chance. I’ve probably been quoted half a dozen times […]

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December 13th, 2020

Brush with Greatness — Rochelle Walensky to Head CDC

There’s an overused expression that, despite its familiarity, really does describe some people perfectly. It’s when you say someone “lights up a room.” My ID colleague and friend Dr. Rochelle Walensky certainly stands as a prime example. Right from the moment we first met during her interviews for ID fellowship in the late 1990s, I noticed […]

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December 6th, 2020

Getting Through a Grim, Dark Winter with Little Bits of Joy

The season’s first nor’easter came barreling through New England this weekend, bringing with it an added level of gloom to an already pretty grim time. Grim because the virus sadly returned right on time, just like the other seasonal coronaviruses — and just like the virologists told us it would. Short days, cold dark nights, wintry mix […]

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