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April 17th, 2008

Required Reading: Bat-Related Human Rabies

A group of researchers in Canada have done infectious diseases experts a big favor — they’ve summarized a staggering amount of useful data on bat-related cases of human rabies in a paper just published in Clinical Infectious Diseases.

(Note to non-ID specialists: infectious diseases doctors spend a lot of time answering questions about rabies in general and the vaccine and bats in particular. I’m fairly certain that being a bat expert was not listed in my job description when I signed up for this field, but maybe that’s because there was no job description.)

This paper should be required reading for all ID docs. Whether the news is reassuring or terrifying will depend on whether you’re a glass half-full or half-empty type of person. Here are some of the key points:

  • Bat-related human rabies is incredibly rare: Since 1950, there have been 56 cases of bat-variant rabies in the United States and Canada, for an average annual incidence of just under one case per year. In several years, there were no cases; in the worst year on record (2001), there were five cases.
  • The overall incidence rate of bat rabies in humans is 3.9 cases per billion person-years. Your odds are better — much better – of winning a huge payout in the lottery, but you don’t need to be a statistician to figure out that neither one of these events (bat rabies or lottery bonanza) is particularly likely.
  • Of the 56 people with bat-variant rabies, 31 (or 55%) had direct contact with a bat (i.e., they were either bitten by one or touched by one), and 6 others (11%) found bats in their home (including 2 in the room where they slept). And here’s the creepy part: 19 (34%) reported no bat exposure whatsoever.
  • Many states have never had a case of bat-related rabies, including Massachusetts (hooray!) and large chunks of the Midwest and Southwest, including both Dakotas, Nebraska, Kansas, Wyoming, Colorado, Arizona, Utah, and others. Among remaining states, most have had 1 case, but California and Texas have not been so lucky, leading the way with 8 and 7 cases, respectively.

The paper has other fascinating non-epidemiologic information for ID docs who may want to brush up on their bat facts, including that the behavior of rabid bats “is not always dramatically altered.” Some rabid bats “may simply become disoriented, lose their flying ability, and appear clumsy.” (Who knew?) Bat bites, furthermore, leave puncture marks <1 mm in diameter, and bat scratches are usually <1 cm long — hence explaining those 19 cases with “no” bat exposure. In all likelihood, they just didn’t notice the small bite or scratch.

All of which leads to the key question of how we can get from a small number of human rabies cases per year down to zero. One possible solution, of course, is to administer the rabies vaccine to anyone with even potential (as opposed to reported) bat exposure. Indeed, in 1999 (and just updated here), the Advisory Committee on Immunization Practices from the CDC recommended administration of rabies vaccine to:

“…persons who were in the same room as the bat and who might be unaware that a bite or direct contact had occurred (e.g., a sleeping person awakens to find a bat in the room or an adult witnesses a bat in the room with a previously unattended child, mentally disabled person, or intoxicated person).”

This has always struck me as a somewhat bizarre recommendation given the inappreciable nature of bat bites and scratches — why does seeing a bat flying around your child’s room mean that this same bat hasn’t flown around your room too? And if you awake to find a bat flying around your room, but your significant other sleeps through the bat visit, should you get the vaccine but your soundly sleeping partner skip it? These are rhetorical questions.

My opinion: some, if not most, of our prevention strategies for bat rabies are really about trying to do something rather than nothing — a completely understandable human impulse given that the survival rate for human rabies is practically zero. After all, no one wants to be the ID doctor who advised against the rabies vaccine when the first-ever case of bat-related human rabies happens in Illinois (or Massachusetts, for that matter).

But I don’t think we should be fooling ourselves that recommending rabies vaccine for these possible bat exposures is going to have much of an impact on the rate of bat rabies in humans, which is already reassuringly low …

… or is it? (Key dramatic music here.)

23 Responses to “Required Reading: Bat-Related Human Rabies”

  1. Great article! I am hoping you will let me post it as a resource on my website? I won’t make any changes, and will credit you, and link back.

    I am a bat exclusion professional. Everyday I run into people with various levels of fear regarding bats. All my employees get the pre rabies vaccination – then follow up shots if/when we get bit.

    There is one additional thing that can be done if you have contact with a bat (or wake up with it in the room). As I explain in my article “What to do with a Bat in the House” (http://www.GetBatsOut.com/batinhouse.htm) – the bat itself can be tested for rabies. This often saves hundreds or even a couple thousand dollars for family rabies shots, and provides considerable peace of mind.

    Michael

  2. Paul Sax says:

    >>I am hoping you will let me post it as a resource on my website?

    That would be great, thank you.

    Thanks also for the reminder about getting the bat tested — can be very reassuring and save lots of time/$.

    Just have to make sure the bat has health insurance before bringing it in.

    (That was a joke.)

  3. Joe says:

    Vote for clinton…that bat will have health insurance whether it wants it or not!

    Great article.

  4. Kaz mawji says:

    Does this artcle apply to bats in NON-european countries also? Do bats go for pets too?

  5. Paul Sax says:

    This is an paper about bat-related human rabies in the USA/Canada.

    As for whether they “go for pets”, not sure I understand your question … do you mean do people have bats for pets? Or do bats attack pets (such as dogs and cats) too? Regardless, I think you’ve surpassed my bat knowledge with either question!

  6. c. says:

    thanks dr. sax, this was a very interesting article. thanks to mr. koski, too, for mentioning the possibility to test the bat.

    i think the following questions is somewhat related to Kaz mawji’s question: does this article apply to all bats in north america or only to blood sucking bats? (are there any of those in the US??)

    i’m trying to relate the key points of your article to medical practice in central europe.

    c.
    (medstudent)
    austria, europe

  7. Rich says:

    I plucked a dark leaf out of the radiator of my car — only to discover that it was, in fact, a smashed bat.
    Aside from the wriggling horrors, I have been concerned about the possibility of exposure to rabies. How quickly after contact would symptoms develop (and what would they be?).

    Would you recommend shrugging it off? Thoughts?

    Thanks very much…..

    Rich

  8. Deborah Watkins says:

    Excellent article, Dr Sacks! Bat lovers everywhere thank you!

    I am a trained bat rehabilitator that lives in Texas. I am vaccinated, in case anyone is wondering. It is required for me to do what I do.

    Rabies is a blood-borne disease. I can all but guarantee (being a statistician, I don’t GUARANTEE anything! ) that those people who contracted rabies were indeed BITEN by the animal that gave it to them.

    And yes, if a bat would bite a human, it would bite your family pet. But this I know: bat are NOT agressive, even when rabid. If you were bitten (or your pet was), it is likely that you accidently trapped the bat somehow (rolled on it or it was trapped in blankets or the dog house). Bats will avoid contact with other animals with every effort they have (vampire bats excluded)!

    As Dr Sacks explained, rabid bats get clumsy and disoriented (this is from the encephalitis that comes with the progression of rabies – they are in SEVERE pain) – but do not get agressive. And no, it does not have to be a vampire bat. (By the way, vampire bats are restricted almost exclusively to the far south regions of the northern hemisphere, and are EXTREMELY rare in the US (any we might find in the US were probably brought here – they did not come here on their own)).

    As for the gentleman that found the “leaf” on his car. Unless you had an open wound and touched that to the bat’s mouth AND it was still moist… It is practically impossible that you have “been exposed”. I hope that helps.

    NO ONE SHOULD EVER touch a bat with their bare hands. If you encounter one, please put on gloves and if you must attempt to catch it, do so with a towel – this protects the bat as well, and makes it less likely you will crush it. Better yet, get out of the area and call a Bath Rehabilitator immediately. If no one has touched the bat, there is no reason to KILL IT for testing.

    Please see http://www.batworld.org to find a Bat Rehabilitator in your area.

    Again, many thanks to Dr Sacks for this very comforting and informative article.

    Bless you!
    Deborah

  9. Paul Sax says:

    What a great comment. Thank you!

  10. Amy says:

    based on the summaries of the articles, would you say it would be recommended to vaccinate a child who was accidentally scratched by a cat, if you found a dead and torn apart bat in the area the cat had been soon after the scratch happened? is it too farfetched to imagine that the cat could still have had live rabid material on its mouth or claws and then scratched it into the child? The first bat is gone – was not much left – but another dead bat was found a few days later (cat still in the area, not known if the cat killed this one) and was sent for testing. awaiting results. no way to know when the bat was killed; could have been right before the scratch or could have been the night before. the cat climbed up the child’s winter coat before the scratch. child is 8 and had no direct contact with the bat itself.

    what do you think? thanks for the information and for your time!

  11. Amy says:

    also- according to my local health dept. no bats tested have come back positive in my town in recent years, though there have been one or two in a town about an hour away.

  12. Paul Sax says:

    I’d say the risk is pretty darn low … one must always contact the local health dept for “formal” advice, glad you did this!

    Paul

  13. Amy says:

    thanks for the feedback. :) the health dept. just plain does not think my daughter could have been exposed this way. local walk-in clinic told me they probably wouldn’t do the series based on the curcumstances, but to see what the 2nd bat revealed. Pediatrician said the same, and that even though it was VERY unlikely, I would pretty much be “stuck” giving her the rabies series if it came back positive. still waiting and worrying, but a bit less. thanks again!

  14. Jane says:

    Five nights ago I was out by a bonfire and a bat swooped from behind me, brushed against my neck but kept on going. I had my hair pulled back and it first brushed against my ponytail before flying past my neck. I don’t have scratches and didn’t feel bites or anything but the bat fluttering past me. Is there any chance I could get rabies from this?

  15. Paul Sax says:

    Jane, sounds “low risk”. But if there’s any chance of a bite, I’d definitely get the vaccine!

  16. butterflydi says:

    Jane,
    I was brushed on my arm by something 7 weeks ago when I was outside just after dark. I never felt a bite, only wings. Later on, when I looked at my arm, I did have a small red bump a little higher up than where I’d felt the wings. I have talked to a lot of people in the meantime, and the majority tell me that I would have felt a bite. I have talked with multiple bat rehabilitators and the state and county dept. of health. I even talked with some other states’ dept. of health to get other opinions. Most of the government officials say “better to be safe than sorry”, but all the bat rehabbers, who’ve actually been bit by bats, say there’s no way you wouldn’t feel the prick. I do not want to take the vaccine and risk the chance of side effects unnecessarily, so this has left me stuck in the middle all these weeks. I have worried myself sick, and have lost a lot of sleep, done enough research on bats and rabies to last a lifetime, and have lost about 1/2 pound a day during this process. Did you make a decision yet?

  17. Polprav says:

    Can I quote from myself with the link to you?

  18. Paul Sax says:

    >>Can I quote from myself with the link to you?

    No problem!
    Paul

  19. Sue-NJ says:

    Hello,
    Recently, my husband, six year old son and myself awoke to discover a bat flying around in the bedroom.
    We exited the room, closed the door and called township animal control. They arrived four hours after the call and could not locate the bat. It seems the attic entrance was cracked open a bit and they think it went back up there.
    After talking with two health departments and three different doctors, the general consensus was that my entire family recieve the post exposure rabies shots. My husband and I have four children and we are all receiving the treatment now.
    We are having a bat exclusion done on the house since a family was found living in the attic.
    My main concern is how safe is the vaccination for us, especially my children.
    I realize the chance of any of us being bitten are extremely low. But, that minute chance and the fact that once a person shows signs of rabies, there’s pretty much no hope for them, led me to accept the shots for my family.
    Again, I’m seriously concerned with any adverse reactions or long term affects we might experience from the shots.
    We are a natural minded family and question any type of immunization. Now, as a mom I’m having to get all four of my kids this series of shots.
    Any thoughts you may have would be greatly appreciated.
    So many people are telling us we should just relax and that they wouldn’t receive the shots if it were them. When I educated myself on rabies, I didn’t want to take any chances with the slightest possibility of any member of my family being bitten.

  20. Paul Sax says:

    Sue,
    A decision about preventive care in the context of a possible exposure must be made personally … and that’s what I’d advise you to do. If the anxiety of the exposure is greater than that of getting the vaccine, then get the vaccine. Be reassured that regardless of what you do, the numbers are overwhelmingly on your side!

    Here’s some more data from that same research group:
    http://blogs.jwatch.org/hiv-id-observations/index.php/2009/05/07/human-rabies-from-bats-another-look-at-the-numbers/

    Paul

  21. Sue says:

    Thank you for your reply.
    I also appreciate the link. The information I read was pretty much what I expected. I think my family has a better chance of winning the lottery than of having rabies.

    Nontheless, we decided to get the series of shots. Like the article said, the chances are unlikely. But, because I’m not only thinking of myself, but of my four children, we’re all getting the series.

    The only side effects we’ve had have been pain at the injection site.
    I’ve felt like I had a very mild flu on each day we receive a shot. It could just be my nerves. We’ve yet to see what our insurance company decides to cover after all of this.

    If it were anything than rabies, I would not have given my consent for the shots. However, the prognosis given after the onset of symptoms was something I couldn’t chance for my family.

    Thank you for the great information!
    Sincerely,
    Sue

  22. Nikki says:

    Sue,
    My family and I are in the exact same boat as yourself!! Same exact dilemma. I too could not take even the slightest chance. I am also naturally minded. My husband was out of town when this happened, so between many phone calls, talks with peds., ER’s, epidem. animal control..we decided, in this case, it was better to err on the side of caution. MMR..can be survived. Rabies. No chance. In fact, after doing all of the research, it doesn’t bother me a bit that we will have some immunization. This is not just in Africa, this is here in our backyards. 3 years ago, we had a fluke incident where a bat flew in. It tested positive for rabies. That partly played into my decision to err on the side of caution. No real side effects here either. Remember, as natural minded moms, we have many things we can do to detox after the shots. Just look up Vaccination Detox.

  23. Doug says:

    Dear Dr Sax,

    I had a question regarding your thoughts on Rabies Post-Exposure Prophylaxis in the following case:

    Yesterday morning my wife, youngest daughter and I awoke to the sound of a bat flying around our hotel room just north of Paris. Our window had been open for several hours as it had been quite warm the evening prior. At any rate, I jumped-up as soon as I became aware of our intruder’s aerial display and ushered him out the window without further incident much to my wife’s amusement and three year-old’s delight.

    “A bat! Just like Halloween!” was her smile-filled response.

    I proceeded to shut the window, hop back into bed and then lay down only to be haunted by something I read while studying for my emergency medicine boards years ago about initiating Rabies PEP in people awakening to winged mammals in their vicinity.

    My question specifically is: “Do you recommend the reduced (4-dose) vaccine schedule endorsed by the CDC’s Advisory Committee on Immunization Practices from March 2010 or the traditional 5-dose regimen?”

    Thanks for your thoughts and best regards,
    Your neurotic colleague-abroad,

    Doug, MD

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HIV Information: Author Paul Sax, M.D.

Paul E. Sax, MD

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Infectious Diseases

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