An ongoing dialogue on HIV/AIDS, infectious diseases,
October 14th, 2013
MODERN Study Stopped: An NRTI-Sparing, Two-Drug Initial Regimen Disappoints Again
In case you didn’t know, “MODERN” is the clever name for the “Maraviroc Once-daily with Darunavir Enhanced by Ritonavir in a New regimen” trial, which compared TDF/FTC to maraviroc, both with boosted darunavir. And once again, the NRTI-sparing two-drug regimen comes up short, this time in a fully powered, double-blind noninferiority study. From a PDF provided by […]
September 4th, 2011
“Novel” Approaches to Initial HIV Therapy: Part II
Two studies were just published on alternative strategies for initial HIV therapy. I’ve already reviewed the first one here. The second paper is a single-arm (n=112) study of darunavir/r (once daily) plus raltegravir, the latest riff on the “NRTI sparing” approach. As I mentioned when I first covered this study, the high rate of virologic failure — […]
Paul E. Sax, MD
Contributing Editor
NEJM Journal Watch
Infectious Diseases
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