The new zoster vaccine is very “reactogenic.” Pain and swelling at the injection site, malaise, generalized aches, symptoms sometimes bad enough to interfere with daily activities. The incidence of these side effects is much higher with RZV than with the live virus vaccine, presumably due to the adjuvant that makes it so immunogenic — and effective. Warn your patients! And as noted above, I strongly suggest all clinicians watch the video, which is embedded at the end of this post — it’s highly informative and useful.
Multiplex respiratory panels face off in a head-to-head study. Isn’t it extraordinary that we can make a definitive diagnosis of what causes respiratory infections with a single nasopharyngeal swab? Nineteen different pathogens in this particular panel. The key to getting these tests more broadly adopted is decreasing the cost of implementation. Nonetheless, this approach is (in my opinion) the future, especially from a hospital infection control standpoint — even though for most of these viruses, there is no available therapy.
More testing for C. diff artificially increases the rate of diagnosis. Nucleic acid testing for C. diff identifies carriers as well as people with the disease — hence the more we test, the more non-disease cases we “diagnose.” This finding is important, as healthcare associated infections such as C. diff are a major hospital quality metric. (Note I avoided writing the full first name of C. diff, very much intentionally as a protest about the discouraging news in the next link.)
A person is ranking all 205 Beatles songs. This effort joins prior similar lists, likethis one, of 213 songs — about which I have major disagreements on his rankings. This time the anonymous author is posting a new one almost every day, which adds to the fun. For Beatles fans, be warned — a huge time sink!
Pitchers and catchers, music to my ears!
And take it away, Dr. Fryhofer — nice job on this video!