March 14th, 2021

Really Rapid Review — CROI 2021 Virtual

For a few years in the early 2010s, the Conference on Retroviruses and Opportunistic Infections (CROI) — in my opinion our premiere HIV scientific meeting — covered almost as many hepatitis C clinical trials as those on HIV. Or at least it seemed that way.

This made sense at the time — the startling success of non-interferon-based HCV treatments made for exciting news, and rapid progress. Here’s what I wrote in 2013 in another patented, copyrighted, and trademarked CROI Really Rapid Review™, for which NEJM Journal Watch receives many millions of dollars in royalties:

The results of the sofosbuvir and ledipasvir study — 100% response in both naives and prior null responders — provided one of the more exciting clinical trial results I’ve seen in years, small sample size notwithstanding.

Remember those days? Well, this CROI had barely any HCV at all, a sign of progress.

(And I was kidding about the royalties, in case you were wondering.)

Of course, in 2021 we are in the midst of a pandemic, so it’s not surprising that this CROI had plenty of COVID-19 studies, both on COVID-19 alone and on the combination of HIV and COVID-19. Here are some highlights, starting with HIV, then the HIV/COVID-19 studies, and then some interesting COVID-19 alone papers.

The links are to the presented abstracts, which requires a conference account (at least it does today) — however, as with other HIV meetings, plenty of the presented material appears on the invaluable NATAP page.

You’ll note I started and finished this post mentioning hepatitis C studies — which due to our success in treatment now have a very small footprint at CROI. Let’s hope the same happens to COVID-19 in the not-so-distant future!

And since this CROI was supposed to be Chicago and bring in people from all over the country (and the world), here’s a wonderful tour around North American accents, with of course a stop in the land of da Bears — right around 3’40”.


2 Responses to “Really Rapid Review — CROI 2021 Virtual”

  1. Sylvain Meylan says:

    Hi Paul! You may not get royalties but your white coat will be retired by the BWH and you will be a first round pick for the NEJM hall of fame. Best regards, Sylvain.

  2. Shubha Kerkar says:

    Thank you for a balcony View -of CROI and for a great Rapid -yet sumptuous summary of CROI 2021!!

HIV Information: Author Paul Sax, M.D.

Paul E. Sax, MD

Contributing Editor

NEJM Journal Watch
Infectious Diseases

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