HIV and ID Observations

December 22nd, 2010

Holiday Hafnias

Some items to consider in HIV/ID world as you dig into your salmonella-free holiday bird: Drug label change for stavudine (d4T):  The label no longer has recommendations for dose-reduction in case of peripheral neuropathy, and cites data more strongly linking d4T use to lipoatrophy.  The strategy of decreasing the dose to reduce d4T toxicity hasn’t made […]

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December 17th, 2010

Update on Berlin Patient II: Still Cured of HIV

First, who was Berlin Patient I? Second, over in the journal Blood is the latest update on Berlin Patient II, the guy apparently cured of HIV by bone marrow transplantation: We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5Δ32/Δ32 stem cells…  In […]

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December 13th, 2010

My (Second) Favorite Journal Switches Publishers

I absolutely love the journal Clinical Infectious Diseases. It’s easily my second-favorite journal. (Can you guess my favorite? Perhaps this new “About this blog” section will give you a hint.) But back to CID — here’s why I love it: Great content.  Seems every issue has fascinating studies, usually of great clinical relevance to the field of Infectious […]

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December 9th, 2010

Chronic Lyme Tough to Diagnose, Tough to Treat

Over at the Chicago Tribune, there is this superb review of the Chronic Lyme disease issue. Lyme disease is real. The bacterial infection, chiefly transmitted by deer ticks, can cause rashes, swollen joints and inflamed nerves, and usually is curable with a round of antibiotics. But doctors around the country are telling patients with common medical problems […]

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December 6th, 2010

Tough Diagnoses: Neurosyphilis, Then and Now

During Thanksgiving, my brother-in-law — who is a professional musician and also a passionate history buff — gave me a scholarly paper to review on the strange death of the famous American explorer Meriwether Lewis, of “Lewis and Clark” fame. The bottom line?  Lewis may well have had neurosyphilis — at least that’s the premise of the […]

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December 1st, 2010

World AIDS Day: See You in Kuala Lumpur

A few random thoughts on this 2010 World AIDS Day. Now you can mark your calendars for the next three International AIDS Society/World AIDS Meetings:  2011 in Rome, 2012 in Washington, DC — and now, 2013 in Kuala Lumpur, Malaysia.  And what do all 3 of these cities have in common?  Extreme summer heat!  (For Kuala Lumpur, it’s actually […]

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November 29th, 2010

Once-daily Raltegravir “Not Non-Inferior” to Twice-Daily

In your electronic in-box this AM, this press release from Merck: … although the treatment regimen that included ISENTRESS once daily enabled more than 80 percent of patients to achieve viral suppression, ISENTRESS once daily did not demonstrate non-inferiority to the treatment regimen that included ISENTRESS twice daily. Merck said that based on the initial results, […]

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November 17th, 2010

Ferlater Antibiotics

In this absolutely hysterical, laugh-out-loud comedy routine, Mal Z. Lawrence describes a woman at a Catskill hotel, piling danish into her handbag. She calls them “ferlater danish” — as opposed to the ones she’s eating at breakfast, those are “fernow.” Did you ever have one of your patients request “ferlater” antibiotics?  That is, ask that you write […]

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November 4th, 2010

XMRV and CFS: More Yay and Nay

Does XMRV cause Chronic Fatigue Syndrome?  Or more accurately, is it even associated with CFS? I’ve been putting off writing about this for a while, as I knew colleagues of mine had a paper in press on the topic, and I wanted the dust to settle a bit more on the controversy. But of course the controversy, […]

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October 22nd, 2010

How to Figure Out the Length of Antibiotic Therapy

One thing we ID doctors know — that other clinicians simply don’t — is how long to treat a patient with antibiotics. I was reminded of this special power by these recent events: An excellent fellow from the hospital’s Critical Care program rotated through our division recently.  When asked about what she wanted learn from the elective, the […]

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