HIV and ID Observations

July 23rd, 2012

IAS-USA HIV Guidelines Updated

With the International AIDS Conference in Washington just starting, the International Antiviral (ahem) Society-USA has revised its HIV treatment guidelines, updating the 2010 version. As has been the case for several years now, it’s published in JAMA and also available on the IAS-USA web site. It’s a well written, evidence-driven summary of the current state of […]

---

July 1st, 2012

“HAART Era” Now Longer Than “Pre-HAART Era” — Can We Officially Retire “HAART”?

As I’ve shared before, I’m no fan of the term “HAART” and do everything I can to stop people from using it. (I’m a fun guy to have at parties.) I’m returning to this pet peeve of mine because I realized recently that we’ve passed a milestone of sorts: Period of no effective HIV treatment, 15 years (1981-1996) […]

---

June 29th, 2012

HIV Testing Roundup, and a Brief Rant

I’ve written so many times about HIV testing that a complete list of the headlines fills two full web pages. But since the last entry on the topic was more than a month ago, one might think I’ve lost interest in the topic. Never! Three items on the HIV Testing radar, two national, one local. First, for a classic […]

---

June 20th, 2012

Abacavir Becomes the Latest Generic Antiretroviral Agent

Hot on the heels of generic nevirapine comes generic abacavir: On June 18, 2012, FDA granted approval for a generic formulation of abacavir tablets, 300 mg, manufactured by Mylan Pharmaceuticals, indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. FDA has determined that the generic formulation is bioequivalent and, therefore, therapeutically equivalent to the […]

---

June 17th, 2012

For Inpatients, HIV Medication Errors Common — Then Promptly Corrected

Several papers have shown that antiretrovirals may be incorrectly prescribed for hospitalized patients with HIV. How do they do at Johns Hopkins — the site of one of the best comprehensive HIV programs in the country (and perennial US News and World Report #1 Hospital in the Universe)? As described in a new CID paper, investigators reviewed ART […]

---

June 13th, 2012

Questions About HIV Cure, and a Very Funny Quote

The single case of HIV cure following allogeneic bone marrow transplant is in the news again, this time because of data just presented at “The International Workshop on HIV and Hepatitis Virus Drug Resistance and Curative Strategies” (formerly known as the “HIV Resistance Workshop” — how’s that for rebranding?). I’m not at the meeting, which is too […]

---

June 8th, 2012

SPARTAN: Two-Drug, NRTI-Sparing Strategies Continue to Disappoint

Just published is the cleverly named “SPARTAN” study — spartan because it leaves out both NRTIs and ritonavir — and the results are very interesting. Ninety-three treatment-naive HIV-positive study subjects were randomized 2:1 to receive either a two-drug regimen of raltegravir 400 mg BID + atazanavir 300 mg BID, or a standard regimen of TDF/FTC + boosted atazanavir. […]

---

June 2nd, 2012

Cryptococcal Meningitis Study Stopped — Early HIV Therapy Clearly Harmful

From NIAID, an important clinical trial has been stopped early: The Phase IV study … was evaluating whether HIV-infected participants hospitalized with cryptococcal meningitis (CM) but not yet taking antiretroviral therapy (ART) would improve their chances of survival if they began ART while receiving CM treatment as inpatients compared with the standard practice of beginning ART […]

---

May 25th, 2012

Generic Nevirapine Now Available — But the Big One is Next Year

As I’m sure you’ve heard from your patients — as I did — lamivudine (3TC) is now available generically. Now comes news of the release of several generic formulations of nevirapine (NVP), an effective but always somewhat overshadowed medication. Since its approval way back when in 1996, there has always been a solid reason to pick […]

---

May 20th, 2012

News on HIV and HCV Testing, and in Praise of Accurate Screening Tests

Two recent news items reminded me how lucky we are to have some very accurate screening tests for certain infectious diseases. The news: An expert FDA panel backed approval of the first true home test for HIV, the OraQuick mouth swab test. Approval of OraQuick for home use may occur later this year. While home testing for […]

---