An ongoing dialogue on HIV/AIDS, infectious diseases,
September 28th, 2014
New FDA HIV Drug Approvals Unlikely to Have Much Impact, Unless …
And if you’re wondering what the big deal is, welcome to the club. In fact, the Canadians beat us to the punch with more significant approval, the co-formulated darunavir/cobicistat, branded as Prezcobix — which sounds like one favorite British breakfast cereal.
For the record, here are a few reasons why the FDA approval of elvitegravir and cobisistat will likely have little short-term effect on clinical practice:
- Elvitegravir is already available as part of TDF/FTC/EVG/COBI.
- Cobicistat is already available as part of the same single tablet regimen.
- If not coformulated, elvitegravir alone has no major advantages over raltegravir and dolutegravir.
- If not coformulated, cobicistat alone has no major advantages over ritonavir. (Though I gather the pill is smaller. Haven’t seen it yet.)
But — what if they cost less? Especially a lot less?