Posts Tagged ‘NSAIDs’

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March 2nd, 2015

Selections from Richard Lehman’s Literature Review: March 2nd

This week’s topics include NSAID use in patients receiving antithrombotic therapy after MI, sauna bathing, Eugene Braunwald’s lecture on the war against heart failure, and more.


February 24th, 2015

Increased Risk with NSAIDs Following Myocardial Infarction

The cardiovascular safety of nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and diclofenac  has been the subject of considerable uncertainty and controversy. Now a new study published in JAMA raises specific concerns about the safety of these drugs in the highly vulnerable population of people who have had a recent myocardial infarction. Using data from several linked national […]


November 24th, 2014

Selections from Richard Lehman’s Literature Review: November 24th

This week’s topics include the PROTECT-AF trial, the association of inpatient vs. outpatient onset of STEMI with treatment and clinical outcomes, and more.


June 16th, 2014

European Regulators Investigate Cardiovascular Safety of Ibuprofen

The European Medicines Agency announced on Friday that it had initiated a review of the cardiovascular safety of ibuprofen when taken in high doses over an extended period of time. The review will be performed by the Pharmacovigilance Risk Assessment Committee (PRAC). The EMA said that people taking ibuprofen should continue to take it as long as they follow the […]


April 8th, 2014

NSAID Use Associated with Atrial Fibrillation in Older People

Use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the elderly is associated with an increased risk for atrial fibrillation (AF), according to a prospective study in BMJ Open. Using a Dutch cohort designed to investigate risk factors of disease onset in the aged, researchers followed some 8400 people for 13 years. None had AF at baseline (when […]


September 16th, 2013

Selections from Richard Lehman’s Literature Review: September 16th

This week’s topics include the AMPLIFY trial, D2B time and mortality among those undergoing primary PCI, and more.


July 22nd, 2013

Selections from Richard Lehman’s Literature Review: July 22nd

This week’s topics include combined vasopressin-epinephrine and methylprednisolone after in-hospital cardiac arrest, avoiding NSAIDs for patients with heart failure, and more.


May 30th, 2013

Large Meta-Analysis Quantifies Risks Posed by Coxibs and Traditional NSAIDs

Findings from a very large meta-analysis of clinical trials of NSAIDs may now allow physicians to quantify the cardiovascular and gastrointestinal risks associated with these drugs. The results of the Coxib and traditional NSAID Trialists’ (CNT) Collaboration, employing data from more than 350,000 randomized patients, have been published in the Lancet. Here are some of the key findings: The risk […]


February 22nd, 2013

Persistent Chest Pain After Myopericarditis

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Five experts offer their perspectives on a perplexing case involving a young physician patient.


January 10th, 2013

Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs

NSAIDs seem to increase the risks for acute kidney injury when taken along with antihypertensive therapy consisting of a diuretic plus an ACE inhibitior or an ARB.