Posts Tagged ‘COX 2 inhibitors’

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May 30th, 2013

Large Meta-Analysis Quantifies Risks Posed by Coxibs and Traditional NSAIDs

Findings from a very large meta-analysis of clinical trials of NSAIDs may now allow physicians to quantify the cardiovascular and gastrointestinal risks associated with these drugs. The results of the Coxib and traditional NSAID Trialists’ (CNT) Collaboration, employing data from more than 350,000 randomized patients, have been published in the Lancet. Here are some of the key findings: The risk […]


January 12th, 2011

Large Meta-Analysis Explores Cardiovascular Safety of NSAIDs

A large network meta-analysis has found “little evidence” to suggest that any of the commonly used NSAIDs or COX 2 inhibitors are safe in terms of cardiovascular risk. In a paper published in BMJ, Sven Trelle and colleagues analyzed data from 31 trials in which patients receiving an NSAID were compared to another NSAID or placebo. Rofecoxib […]