November 28th, 2014
The FDA said Wednesday that it had granted approval to a novel technology that noninvasively measures fractional flow reserve (FFR) using data obtained from a CT scan of the heart. In recent years a catheter-based form of FFR has been used by interventional cardiologists during catheterization procedures to measure the pressure gradient in partially blocked […]
September 3rd, 2014
The CardioExchange editors ask whether the 2-year findings from FAME 2 are more compelling than the 7-month findings.
September 2nd, 2014
Two studies presented at the European Society of Cardiology meeting in Barcelona offered fresh support for fractional flow reserve (FFR), which has been slowly but surely gaining traction in the interventional cardiology community. FFR in Patients with Stable CAD Bernard De Bruyne presented 2-year results from the FAME 2 (Fractional flow reserve versus Angiography for Multivessel Evaluation […]
July 11th, 2014
Rick Lange and David Hillis wonder whether the debate about the role of FFR and IVUS in patient selection for PCI is a red herring in the larger issue of revascularization in patients with stable CAD.
February 6th, 2013
David Hillis and Rick Lange consider new evidence that iFR is not an acceptable substitute for FFR. Does the need for adenosine administration hinder the use of FFR to guide management decisions?
September 17th, 2012
This week’s topics include surgical vs. lifestyle treatment for type-2 diabetes, omega-3 fatty-acid supplementation and the risk for major CVD events, FAME 2, using high-sensitivity cardiac troponin T for one-hour rule-out or rule-in of acute MI, and the timing of acute MI in patients having total hip or knee replacement.
September 4th, 2012
Larry Husten is back from ESC and discussing two trials that exemplify how medicine is supposed to work, and one that exemplifies what can go wrong, especially when commercial interests are at stake.
August 28th, 2012
Two sharply divergent views have developed about the value of fractional flow reserve (FFR) in PCI. FFR advocates think the new technology can help identify ischemic lesions that will benefit from PCI, thereby helping to salvage or enhance the reputation of PCI. FFR skeptics think that optimal medical therapy is still the preferred option for most […]
May 22nd, 2012
The instantaneous wave-free ratio (iFR) is a pressure-derived index of stenosis severity that does not require adenosine administration. The index was introduced at the 2011 TCT conference and validated by the results of the ADVISE study, published in December 2011. Following a series of presentations at the recent EuroPCR congress, Dr. Justin Davies answers questions […]
May 18th, 2012
In FAME II, a prospective study conducted at 28 centers in Europe and the United States, >1200 patients with ischemia (as determined by fractional flow reserve [FFR]) were randomly assigned to receive (a) PCI (with a DES) and optimal medical therapy (OMT) or (b) OMT alone. The primary endpoint was a composite of death, myocardial infarction […]