Posts Tagged ‘thrombolysis’

March 23rd, 2015

Selections from Richard Lehman’s Literature Review: March 23rd

This week’s topics include antiplatelet therapy duration following bare metal or drug-eluting coronary stents, thrombolysis in acute ischemic stroke, and more.

February 19th, 2015

A Close Examination of Recent Studies of Endovascular Treatment for Acute Ischemic Stroke

Rory Spiegel takes a close look at the MR CLEAN, EXTEND-IA, and ESCAPE trials.

February 12th, 2015

Three Trials Show Benefits of Thrombectomy in Stroke Patients

Three new studies offer important additional evidence that early treatment with current thrombectomy devices that extract clots from blood vessels in the brain can lead to improved outcomes in carefully selected stroke patients. The trials were stopped early based on efficacy following positive findings last year from another trial, MR CLEAN. The three new trials […]

August 11th, 2014

Selections from Richard Lehman’s Literature Review: August 11th

This week’s topics include the effects of intensive glucose control on ischemic heart disease and a meta-analysis of the effects of thrombolysis with alteplase for acute ischemic stroke.

August 5th, 2014

Large Analysis Supports Thrombolysis for Stroke

Although thrombolysis for ischemic stroke has been widely recognized as beneficial, its use has been limited because of concerns about its effects in patients treated after 3 hours, in older patients, and in patients with mild and with severe strokes. Now a meta-analysis published in the Lancet offers evidence that the use of thrombolysis should be […]

June 23rd, 2014

Selections from Richard Lehman’s Literature Review: June 23rd

This week’s topics include thrombolysis for pulmonary embolism, the effect of screening and lifestyle counseling on the incidence of ischemic heart disease in the general population, and more.

June 17th, 2014

A Meta-Look at Thrombolysis vs. Conventional Anticoagulation for PE


Jay Giri and Saurav Chatterjee discuss their meta-analysis of trials comparing thrombolytic therapy and conventional anticoagulation in patients at intermediate risk for pulmonary embolism.

June 17th, 2014

Mixed Results for Thrombolysis in Pulmonary Embolism

  The role of thrombolytic therapy for the treatment of pulmonary embolism has been unclear, as it has been difficult to measure the precise balance between enhanced clot-dissolving efficacy and greater bleeding risk produced by thrombolysis when compared with conventional anticoagulation. A new meta-analysis published in JAMA analyzed data from 16 randomized trials including 2115 patients. Overall, […]

April 28th, 2014

Selections from Richard Lehman’s Literature Review: April 28th

This week’s topics include BP targets during septic shock, reducing time-to-needle times in acute ischemic stroke, and an increase in fat and calorie consumption in U.S. statin users.

August 19th, 2013

Selections from Richard Lehman’s Literature Review: August 19th

This week’s topics include treating to risk, not to target; perceived job insecurity as a risk factor for incident CHD; ischemic preconditioning in patients undergoing CABG, and more.