September 11th, 2014
Boback Ziaeian discusses his observational study exploring the benefits of guideline-recommended cardiac resynchronization therapy and ICD therapy in heart failure patients, according to race and ethnicity.
March 30th, 2014
MADIT-CRT was an influential trial that showed a reduction in heart failure complications — but not mortality — when cardiac resynchronization therapy (CRT) was added to an implantable defibrillator in patients with mild heart failure who also had left bundle-branch block (LBBB). Patients in the trial were followed for 2.4 years, raising questions about the long-term effects […]
September 19th, 2013
Sergio Richter discusses his research group’s study of a non–fluoroscopy-based tracking system that can be used when implanting a CRT device.
September 3rd, 2013
A new study from the Echo-CRT study group shows that CRT is not beneficial in patients with HF and a narrow QRS complex and may even be harmful.
August 19th, 2013
This week’s topics include treating to risk, not to target; perceived job insecurity as a risk factor for incident CHD; ischemic preconditioning in patients undergoing CABG, and more.
August 13th, 2013
A large observational study published in JAMA suggests that patients with left bundle-branch block (LBBB) and longer QRS duration derive the most benefit from a cardiac resynchronization therapy defibrillator (CRT-D). The findings appear to support current, but often criticized, guidelines from the American College of Cardiology, American Heart Association, and the Heart Rhythm Society, in which a class I […]
May 12th, 2013
In recent weeks the cardiac resynchronization therapy (CRT) field has been absorbing the publication of the BLOCK HF trial in the New England Journal of Medicine and the publication of the NARROW-CRT trial in Circulation: Arrhythmia and Electrophysiology. These trials raised the possibility that CRT may improve clinical status in some patients with ischemic cardiomyopathy […]
April 26th, 2013
Two new trials have ended up reporting conflicting results regarding the expansion of the indication for cardiac resynchronization therapy (CRT) for patients without a wide QRS interval. The positive results of the smaller trial seem likely to be undermined by the early stopping of the much larger trial. The first trial, NARROW-CRT, published in Circulation: Arrhythmia […]
April 24th, 2013
Patients with atrioventricular (AV) block generally receive right ventricular (RV) pacing; cardiac resynchronization therapy (CRT) has been restricted to patients with a low ejection fraction and a wide QRS duration. However, RV pacing may worsen LV dysfunction in AV block patients with low ejection fractions. Previous studies have raised the possibility that these patients may […]
March 1st, 2013
The American College of Cardiology (ACC) and the Heart Rhythm Society (HRS) today published appropriate use criteria for implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy (CRT). The document offers an expert consensus on the appropriateness of 369 separate real-life clinical scenarios in six areas: ICDs for secondary prevention, ICDs for primary prevention, comorbidities, CRT devices, generator replacement, […]