CardioExchange Archive

November 25th, 2013

Selections from Richard Lehman’s Literature Review: November 25th

Richard Lehman, BM, BCh, MRCGP

This week’s topics include DAPT cessation and coronary events after PCI, statins and cognitive function, and more.

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November 18th, 2013

No Evidence That Statins Impact Cognitive Function

Larry Husten, PHD

In 2012 the FDA revised the label of statins to include a warning about reports that the drugs had been linked to memory loss or confusion. The FDA action appeared to be based largely on case reports. Despite concerns about this topic that have appeared sporadically in recent years, no high-quality review of the topic has appeared until now. […]

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October 28th, 2013

Selections from Richard Lehman’s Literature Review: October 28th

Richard Lehman, BM, BCh, MRCGP

This week’s topics include thrombus aspiration during STEMI, the effect of statins on mortality in patients with ventilator-associated pneumonia, and more.

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October 3rd, 2013

News From Our ‘Statin Civilization’: High-Dose Statins Found to Reduce Gum Disease Inflammation

Larry Husten, PHD

In addition to their well-known benefits in heart disease, high-dose statins appear to reduce gum inflammation caused by periodontal disease, a new report published in the Journal of the American College of Cardiology shows. The findings offer more evidence that heart disease and gum disease may be linked, and also help support the view that statins achieve at least […]

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September 23rd, 2013

HDL-P: The Better Marker of Residual Risk?

Samia Mora, MD, MHS

CardioExchange Editors interview Samia Mora about her investigative group’s analysis of data from the JUPITER trial, which reveals that HDL-P may be a better marker of residual risk than chemically measured HDL-C or apoA-1.

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September 20th, 2013

Taking a Clear-Eyed View of Statins and Cataracts

Larry Husten, PHD

Past observational studies have turned up conflicting findings about the effects, if any, of statins on developing cataracts. Now a large new observational study finds a small but significant increase in cataracts in statin users, however, experts warn that without further support the new finding should probably not influence clinical practice. In a paper published in JAMA […]

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August 29th, 2013

Statins Reduce Cardiovascular Events in Elders Without Established CVD

Nicholas Downing, MD

Statins are associated with lower risks for myocardial infarction and stroke among elders without established cardiovascular disease, according to a meta-analysis in the Journal of the American College of Cardiology. The analysis included eight randomized, placebo-controlled trials comprising nearly 25,000 patients aged 65 and older without CVD at baseline. During 3.5 years’ follow-up, statin use was […]

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July 29th, 2013

Selections from Richard Lehman’s Literature Review: July 29th

Richard Lehman, BM, BCh, MRCGP

This week’s topics include riociguat for chronic thromboembolic pulmonary hypertension, renal outcomes associated with invasive vs. conservative management of ACS, statins and musculoskeletal conditions, arthropathies, and injuries, and more.

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July 16th, 2013

What You Need To Know About Statins

Huseyin Naci, MHS, PhD Candidate, Jasper Brugts, Md phd msc and Harlan M. Krumholz, MD, SM

The authors of the largest meta-analysis to date on the side effects of statins discuss their findings and weigh the risks and benefits of statins for primary prevention.

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July 9th, 2013

Low Rate of Problems with Statins in Study of Quarter Million Patients

Larry Husten, PHD

A very large analysis of previously published studies finds that statins are generally safe and well tolerated, but helps confirm previous links to a small increased risk for diabetes and elevation of liver enzymes. Some statins were better tolerated than others, and lower-dose statins were better tolerated than high doses. In a paper published in Circulation: Cardiovascular […]

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