August 29th, 2013
Statins Reduce Cardiovascular Events in Elders Without Established CVD
Statins are associated with lower risks for myocardial infarction and stroke among elders without established cardiovascular disease, according to a meta-analysis in the Journal of the American College of Cardiology.
The analysis included eight randomized, placebo-controlled trials comprising nearly 25,000 patients aged 65 and older without CVD at baseline. During 3.5 years’ follow-up, statin use was associated with a 39% reduction in the risk for MI and a 24% reduction in the risk for stroke. The researchers estimate that 24 patients would need to be treated for 1 year to prevent one MI, and 42 to prevent one stroke.
There was a trend toward a reduction in mortality, but this did not reach statistical significance.
The researchers say their study “provides first time evidence” that statins’ cardiovascular benefits extend to people aged 65 and older without CVD.