September 16th, 2013
Combining Randomized Trials And Registries: A New Paradigm
John S Rumsfeld, MD, PhD
Ultimately, we need clinical trials to know what drugs and medical devices work. Without them, we will not have the evidence we need for clinical practice guidelines, and clinical care will not evolve. But traditional clinical trial approaches are not sustainable – too expensive and too inefficient. The new hope for clinical trials is to […]
September 12th, 2013
Aspirin Therapy with Anticoagulation in Patients with Afib?
Benjamin A. Steinberg, MD and John Ryan, MD
An interview with Benjamin Steinberg about an analysis of data from the ORBIT-AF registry, in which patients with atrial fibrillation who were taking oral anticoagulation and aspirin had a higher risk of bleeding than patients on anticoagulation only.
September 1st, 2013
A Disruptive TASTE of the Future?
Larry Husten, PHD
Negative findings from a registry-based randomized trial of pre-PCI thrombus aspiration for STEMI patients
May 23rd, 2013
When Are Dual-Chamber ICDs Necessary for Primary Prevention?
Pam Peterson, MD, MSPH, Frederick Masoudi, MD, MSPH and Nihar Desai, MD, MPH
Pamela Peterson and Frederick Masoudi discuss findings from their research group’s registry study comparing outcomes with dual- versus single-chamber ICDs among primary-prevention patients who have no pacing indication.
April 3rd, 2013
International Cardiovascular Device Registries: The Next Big Thing
Larry Husten, PHD
A new initiative involving a wide variety of stakeholders — the FDA, the American College of Cardiology, the Society of Thoracic Surgeons, industry, medical journals, and others — could lead to an enormous international cooperative effort to make device registries a standard part of the practice of cardiology. This will be a “huge step,” said David […]
April 12th, 2012
Ascertaining ASCERT: How Well Do Registry Data Measure Up to the ‘Bedside Test’?
Øystein Horgmo, BSc
In the ASCERT observational study, stable patients (age 65 or older) with double- or triple-vessel CAD, but not left-main disease, were found to have better long-term survival after CABG than after PCI. ASCERT was a laudable achievement in terms of its scope and the level of collaboration it represents. The ASCERT investigators used inverse probability weighting (propensity […]
January 4th, 2011
Study Suggests Large Proportion of ICD Implantations Lack Firm Evidence Base
John Spertus, MD, MPH
Study Summary by Larry Husten: An analysis in JAMA of the National Cardiovascular Data Registry (NCDR) shows that a substantial proportion of ICD implantations are not supported by a firm evidence base. Sana Al-Khatib and colleagues examined data from 117,707 patients who received ICDs between January 1, 2006 and June 30, 2009, and found that […]