CardioExchange Archive

May 30th, 2013

Large Meta-Analysis Quantifies Risks Posed by Coxibs and Traditional NSAIDs

Larry Husten, PHD

Findings from a very large meta-analysis of clinical trials of NSAIDs may now allow physicians to quantify the cardiovascular and gastrointestinal risks associated with these drugs. The results of the Coxib and traditional NSAID Trialists’ (CNT) Collaboration, employing data from more than 350,000 randomized patients, have been published in the Lancet. Here are some of the key findings: The risk […]

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September 29th, 2011

Meta-Analysis Explores Real World CV Risk of NSAIDs

Larry Husten, PHD

A new meta-analysis sheds additional light on the cardiovascular risk of NSAIDs as used in the real world, including low doses of the most popular drugs, over short periods, and in low-risk populations. In a paper published online in PLoS Medicine, Patricia McGettigan and David Henry analyzed data from 30 case-control studies including 184,946 CV events and […]

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May 10th, 2011

Short-Term NSAID Use Linked to Increased CV Risk

Larry Husten, PHD

Short-term use of NSAIDs, including diclofenac, is associated with increased cardiovascular risk, according to a very large study published online in Circulation. Danish researchers used a national registry to study more than 83,000 patients who were admitted to the hospital for a first MI from 1997 to 2006. Some 42% of the patients received NSAIDs during […]

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