Posts Tagged ‘decompensated heart failure’

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May 27th, 2014

Selections from Richard Lehman’s Literature Review: May 27th

This week’s topics include mortality trends in patients with diabetes, cardiovascular remodeling in CAD and HF, and more.


December 17th, 2012

Selections from Richard Lehman’s Literature Review: December 17th

This week’s topics include a study on ICD programming to reduce inappropriate therapy and mortality, a clinical review of diagnosing and managing supraventricular tachycardia, the Global Burden of Disease Study 2010, and more.


November 30th, 2010

ASCENDing Into the Depths of the Nesiritide Controversy: Questions for Eugene Braunwald

Results of ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial), presented as a late-breaking clinical trial at the AHA meeting, showed that there were no significant differences in the pre-specified endpoint of dyspnea among some 7,000 patients with acute, decompensated HF randomized to receive standard therapy and either continuous intravenous nesiritide or placebo. This trial was started in […]


November 14th, 2010

ASCEND-HF: Nesiritide Is Safe But Not Effective

ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure Trial) was started in response to the enormous controversy over the safety and efficacy of nesiritide, which was being used in growing numbers of heart failure patients.  The trial randomized 7141 patients with acute, decompensated HF to receive standard therapy and either continuous intravenous nesiritide or placebo. Results of ASCEND-HF, presented as a […]