January 30th, 2013
Does a patient’s insurance status affect a physician’s decision to prescribe evidence-based therapies for CAD?
January 28th, 2013
The enormous success of ACE inhibitors in hypertension and heart failure spurred hope that adding a second drug to block the renin-angiotensin system would yield improved outcomes. Although definitive evidence supporting dual blockade of the renin-angiotensin system has never been found, more than 200,000 patients in the U.S. currently receive this therapy. Now a large new meta-analysis […]
January 10th, 2013
NSAIDs seem to increase the risks for acute kidney injury when taken along with antihypertensive therapy consisting of a diuretic plus an ACE inhibitior or an ARB.
August 8th, 2012
This week’s topics include heart failure and depression, endoscopic vs. open vein-graft harvest for CABG, linagliptin vs. glimepiride in those with type-2 diabetes, weight gain with smoking cessation, ACE inhibitors and pneumonia risk, and the effect of speech therapy after stroke.
July 13th, 2012
Angiotensin-converting–enzyme inhibitors may offer some protection against pneumonia, according to a BMJ meta-analysis. An editorialist isn’t so sure. Researchers looked at almost 40 studies — including cohort studies, case-control studies, and randomized trials — that reported pneumonia outcomes after use of ACE inhibitors, angiotensin-receptor blockers, and control treatments. The data revealed that ACE inhibitors conferred a roughly 30% […]
July 3rd, 2012
Although current guidelines recommend that ACE inhibitors and angiotensin-receptor blockers (ARBs) be used in high doses in patients with congestive heart failure, many CHF patients currently receive lower than recommended doses of these drugs. In a research letter published online in Archives of Internal Medicine, investigators in Montreal analyzed data from 43,405 patients with a first hospital […]
February 13th, 2012
This week’s topics include communicating with patients about screening and treatment and the association between blood-pressure-lowering drugs and gout.
October 19th, 2011
Although the teratogenic properties of ACE inhibitors in the second and third trimesters of pregnancy are well-documented, the effects of their use in the first trimester have been unclear. Now a study suggests that hypertension itself, rather than ACE inhibitors or other antihypertensive drugs, is the likely cause of an increased risk for birth defects […]
November 1st, 2010
The real-world incidence of ACE inhibitor-associated cough is much higher than the reported rate on drug labels and printed in the Physicians’ Desk Reference, according to a study published in the American Journal of Medicine. Sripal Bangalore and colleagues analyzed data from 125 published studies with ACE inhibitors including almost 200,000 patients. They found that […]