April 27th, 2015
Through the Fog of Data on Endovascular Therapy for Acute Ischemic Stroke
Rory J Spiegel, MD
Perspective on an array of trials of endovascular therapy for acute ischemic stroke — and on the potential consequences of early trial cessation.
April 2nd, 2015
Liberal Changes to rt-PA Contraindications for Acute Ischemic Stroke
Craig Cocchio, PharmD, BCPS
Dr. Craig Cocchio discussing changes to the contraindications for acute ischemic stroke, about which the FDA has been curiously silent.
March 16th, 2015
Selections from Richard Lehman’s Literature Review: March 16th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include endovascular therapy for ischemic stroke with perfusion-imaging selection, innovation and implementation in CV medicine, statin intolerance, and more.
December 24th, 2014
An Examination of MR CLEAN
Rory J Spiegel, MD
Rory Spiegel examines why the MR CLEAN trial of interventional therapy for acute ischemic stroke succeeded where its predecessors failed.
December 17th, 2014
Dutch Trial Gives Support to Thrombectomy for Ischemic Stroke
Larry Husten, PHD
A large new trial provides the first substantial evidence that thrombectomy may be beneficial in patients with acute ischemic stroke. Previous thromboectomy trials have been disappointing; some experts have speculated this may be due to the use of early-generation devices, long treatment delays, and difficulties in recruiting suitable patients into the trials. The Multicenter Randomized Clinical […]
December 19th, 2013
Early Doses of Warfarin Paradoxically Associated with Higher Stroke Risk
Patients with atrial fibrillation seem to be at increased risk for ischemic stroke when starting warfarin prophylaxis, according to a case-control study in the European Heart Journal. The study was undertaken after trials of both apixaban and rivaroxaban noted increased stroke risks among patients transitioning to open-label warfarin. This study was funded by the makers of apixaban. […]
August 28th, 2012
Selections from Richard Lehman’s Literature Review: August 28th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include studies on biolimus-eluting stents vs. bare-metal stents, risk markers to improve CV event prediction, common carotid intima-media thickness and CV risk prediction, aspirin with alteplase for acute ischemic stroke, and lipid-lowering therapy (and its benefits and harms) in patients with CKD.
July 2nd, 2012
Selections from Richard Lehman’s Literature Review: July 2nd
Richard Lehman, BM, BCh, MRCGP
This week’s topics include pay for performance, Don Berwick’s Harvard commencement address, tPA for ischemic stroke in warfarin-treated patients, surgery for infective endocarditis, the American health care system, and the record number of RECORD studies.
June 25th, 2012
Selections from Richard Lehman’s Literature Review: June 25th
Richard Lehman, BM, BCh, MRCGP
This week’s topics includes articles on industry regulation, the chronically comorbid, population risk for CV disease, and recombinant tissue plasminogen activator (rt-PA) for ischemic stroke.
NEJM Journal Watch — Recent Cardiology Articles- Persistent Symptoms After Valve Replacement for Severe Aortic Stenosis
- Is Diltiazem Safe in Patients with AF Taking Apixaban or Rivaroxaban?
- Does Lowering High Childhood Lipid Levels Prevent Adverse Cardiovascular Events in Adulthood?
- Self-Expanding Supraannular Valve vs. Balloon-Expandable Valve in TAVR for Small Aortic Annulus
- A New TAVR Prosthesis for Aortic Regurgitation Shows Promise