November 25th, 2013
Does Suppressing Gastric Acid Cause Community-Acquired Pneumonia?
Ever since early observational studies documented an association between acid suppression and pneumonia, many clinicians have assumed this association meant causation. This intrigues me because results of numerous prospective trials that have controlled for underlying patient comorbidities have refuted any causative effect. Moreover, acid suppression does not result in a gastric environment conducive to bacterial […]
November 6th, 2013
Iron Deficiency Anemia: When Do We Stop Scoping?
It is standard practice to perform endoscopy in patients with iron deficiency anemia who have evidence of gastrointestinal bleeding or other symptoms. Even in the absence of symptoms, in patients aged 50 years or older, who are at increased risk for colorectal cancer, age alone would indicate that at least a colonoscopy is in order. […]
M. Brian Fennerty, MD
Editor-in-Chief
NEJM Journal Watch Gastroenterology
Biography | Disclosures | Summaries
Learn more about Gut Check on Gastroenterology.
From NEJM: Recently in Gastroenterology- Herpes Simplex Virus Esophagitis September 27, 2025A 29-year-old woman presented with a 2-day history of painful swallowing. One week earlier, she had had a fever and sore throat. Upper endoscopy revealed multiple “volcano-like” ulcers in the middle esophagus.
- CD19 CAR T-Cell Therapy in Multidrug-Resistant Ulcerative Colitis September 25, 2025In a patient with treatment-resistant ulcerative colitis, CD19 CAR T-cell therapy led to drug-free remission and mucosal healing, suggesting that B-cell targeting may offer a novel therapeutic pathway.
- Ultraprocessed Food on an Ultrafast Track September 18, 2025The Nova food-classification system has advanced efforts to address modern diets of highly processed foods. But it’s unclear whether it can be codified at a national level to support public health.
- Herpes Simplex Virus Esophagitis September 27, 2025