Posts Tagged ‘supplements’

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March 17th, 2014

Studies Provide Little Support for Guidelines on Dietary Fats and Supplements

The precise cardiovascular effect of dietary fats and supplements has been the subject of heated controversy. Although there is no strong supporting evidence from clinical trials, current guidelines tend to discourage or minimize the role of saturated fats and trans fats and to encourage the intake of omega-3 polyunsaturated fatty acids. Two new studies published today help clarify […]


February 24th, 2014

Vitamin Supplements Come Up Short Once Again

Once again, the U.S. Preventive Services Task Force (USPSTF) has concluded that there is no good evidence to support the routine use of multivitamins or most individual or combination vitamins by healthy adults to prevent cardiovascular disease or cancer. The USPSTF also recommended against the use of two specific vitamins — beta-carotene and vitamin E. Beta-carotene has been […]


December 16th, 2013

Case Closed: Multivitamins Should Not be Used

The editorialists are fed up: “Enough is enough.” Writing about three new papers in the Annals of Internal Medicine that find no benefits for the use of multivitamins — only the latest in a long line of negative findings — Eliseo Guallar and colleagues write: …we believe that the case is closed — supplementing the diet of well-nourished adults […]


July 11th, 2013

Link to Prostate Cancer Brings More Bad News for Fish-Oil Story

Adding more confusion to an already fishy story, a new study has found a significant association between omega-3 fatty acids and the risk of prostate cancer. Although the link had been previously observed, the finding surprised the investigators, who wrote that “these findings contradict the expectation that high consumption of long-chain omega-3 fatty acids and low consumption […]


September 11th, 2012

More Evidence That Omega-3 Supplements Don’t Work

Once again researchers have failed to find any clinical benefit for omega-3 supplements. In a new meta-analysis and systematic review published in JAMA, Evangelos Rizos and colleagues analyzed 20 randomized controlled trials including  68,680 patients and found no significant effect on any of the endpoints: all-cause mortality: relative risk (RR) 0.96, CI 0.91 – 1.02 cardiac death: RR […]


April 9th, 2012

Meta-Analysis: No Secondary CV Prevention Benefits for Omega-3 Fatty Acid Supplements

A new meta-analysis published in the Archives of Internal Medicine finds no evidence to support claims of a beneficial effect of omega-3 fatty acid supplements on secondary CV prevention. Sang Mi Kwak and colleagues in the Korean Meta-analysis Study Group analyzed data from more than 20,000 patients with a history of CV disease who were randomized in […]


August 3rd, 2010

Vitamin B Trial Finds No Clinically Significant Benefit

The VITATOPS (The VITAmins TO Prevent Stroke) Trial randomized 8164 patients with recent stroke or TIA to either placebo or B vitamins. After a median followup of 3.4 years, the primary endpoint — the combined incidence of stroke, MI, or vascular death — occurred in 616 patients in the B vitamin group and 678 in the placebo […]