Posts Tagged ‘renin inhibition’

November 3rd, 2012

ALTITUDE Autopsy Shows What Went Wrong With Aliskiren

In its short lifespan the direct renin inhibitor aliskiren (a.k.a., Rasilez or Tekturna) rapidly declined from being a highly promising, first-of-its kind drug to a major failure. The death blow was struck last December with the early termination of the ALTITUDE trial, after the data and safety monitoring committee found an increased risk in patients taking aliskiren. Now the final results […]

August 26th, 2012

First Detailed Look At Why Aliskiren Failed To Gain ALTITUDE

This once-promising renin inhibitor was no better than placebo when it came to the composite outcome, but showed worrisome trends, especially when it came to stroke.