Posts Tagged ‘renin-angiotensin system antagonists’

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November 9th, 2013

Yet Another Blow to Combination Renin-Angiotensin-Aldosterone System Blockade

ACE inhibitors and angiotensin-receptor blockers have been found to effectively slow progression of kidney disease. It has been theorized that dual blockade of the renin-angiotensin-aldosterone system (RAAS) might prove even more beneficial, but these hopes have not been realized. Now a new trial published in the New England Journal of Medicine throws further cold water on the once-promising hypothesis. […]


May 21st, 2013

European Medicines Agency Starts Review of Combined Use of Drugs that Block the Renin-Angiotensin System

The European Medicines Agency (EMA) said last week that it was initiating a review of the combined use of agents that block the renin-angiotensin system (RAS). The three classes of RAS-blocking drugs (ACE inhibitors, ARBs, and direct renin inhibitors) are used to treat hypertension and congestive heart failure. The EMA said that the review was being performed to […]


December 3rd, 2012

Selections from Richard Lehman’s Literature Review: December 3rd

This week’s topics include the association between aldosterone-antagonist therapy and mortality and readmission among patients with HF and reduced EF, warfarin therapy after bioprosthetic AVR, and more.