Posts Tagged ‘PFO Closure’

March 25th, 2013

Selections from Richard Lehman’s Literature Review: March 25th

This week’s topics include the effect of aliskiren on postdischarge mortality and readmissions among those hospitalized for HF, PFO closure, and more.

March 20th, 2013

Controversial PFO Closure Trials Published in NEJM

Two controversial trials testing PFO closure in patients with cryptogenic stroke missed their primary endpoints but contained suggestions of possible benefit.

November 20th, 2012

PFO Occluder Devices Don’t Get No RESPECT

David Hillis invokes Rodney Dangerfield in considering the findings of a recent trial of a PFO closure device.

October 25th, 2012

TCT: Two PFO Closure Trials Miss Primary Endpoints

Two trials presented today at the TCT meeting in Miami testing the benefits of PFO closure in patients with cryptogenic stroke have failed to convincingly demonstrate any significant  benefit for the controversial procedure. The RESPECT (Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment) trial randomized 980 patients to PFO closure with the […]

July 24th, 2012

St. Jude Spills the Beans on PFO Closure Trial

Larry Husten asks readers to assess the ethical dimensions of St. Jude’s recent statements about the RESPECT trial.

May 6th, 2012

Patent Foramen Ovale — Are the Choices Patently Obvious?


Shelby Kutty explains what we know and what we don’t know about how to manage patients with a PFO.

March 19th, 2012

Selections from Richard Lehman’s Literature Review: Week of March 19th

This week’s topics include percutaneous PFO closure and dabigatran risks.

March 14th, 2012

Achieving CLOSURE: Final Act of PFO Closure Device Trial

Nine years after getting underway, results of the CLOSURE 1 trial of PFO closure for cryptogenic stroke are finally published in the New England Journal of Medicine.

March 14th, 2012

The $800 Million Gamble: Jumping Aboard or Jumping the Gun?


In the CLOSURE I trial (Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack Due to a Presumed Paradoxical Embolism through a Patent Foramen Ovale), 909 patients with a PFO who had a stroke or a transient ischemic attack (TIA) of unclear etiology were randomly assigned to device […]

November 15th, 2010

Let’s Bring CLOSURE to This Debate About PFO Treatment

In this blog, Rick Lange tells us how he would answer FAQs about PFO closure to prevent stroke. The controversy: Based on retrospective and nonrandomized studies, many physicians are convinced that percutaneous patent foramen ovale closure can reduce rates of cryptogenic stroke and transient ischemic attack. Although PFO closure devices are approved for stroke prevention in Europe […]