Posts Tagged ‘perioperative beta blockade’

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September 8th, 2014

Selections from Richard Lehman’s Literature Review: September 8th

This week’s topics include the PARADIGM-HF trial, sham controls in medical-device trials, the efficacy of β blockers in patients with heart failure and atrial fibrillation, and more.


July 31st, 2013

European Heart Guidelines Based on Disgraced Research May Have Caused Thousands of Deaths

Despite a 2-year-old scandal discrediting key evidence, current guidelines relying on this evidence have not been revised. As a result of physicians following these guidelines, some researchers say, it is possible that thousands of patients may have died each year in the U.K. alone. It is unlikely that a true understanding of the damage will […]


April 29th, 2013

Selections from Richard Lehman’s Literature Review: April 29th

This week’s topics include the association of perioperative beta-blockade with mortality and CV morbidity following major noncardiac surgery, intestinal microbial metabolism of phosphatidylcholine and CV risk, and more.


April 23rd, 2013

Study Suggests Benefit for Beta Blockers During Noncardiac Surgery

The use of perioperative beta-blockade for noncardiac surgery has been declining as a result of the controversial POISE study, which turned up evidence for harm associated with extended-release metoprolol in this setting. Now a large new observational study published in JAMA offers a contrary perspective by suggesting that perioperative beta-blockade may be beneficial in low- […]