CardioExchange Archive

September 8th, 2014

Selections from Richard Lehman’s Literature Review: September 8th

Richard Lehman, BM, BCh, MRCGP

This week’s topics include the PARADIGM-HF trial, sham controls in medical-device trials, the efficacy of β blockers in patients with heart failure and atrial fibrillation, and more.

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July 31st, 2013

European Heart Guidelines Based on Disgraced Research May Have Caused Thousands of Deaths

Larry Husten, PHD

Despite a 2-year-old scandal discrediting key evidence, current guidelines relying on this evidence have not been revised. As a result of physicians following these guidelines, some researchers say, it is possible that thousands of patients may have died each year in the U.K. alone. It is unlikely that a true understanding of the damage will […]

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April 29th, 2013

Selections from Richard Lehman’s Literature Review: April 29th

Richard Lehman, BM, BCh, MRCGP

This week’s topics include the association of perioperative beta-blockade with mortality and CV morbidity following major noncardiac surgery, intestinal microbial metabolism of phosphatidylcholine and CV risk, and more.

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April 23rd, 2013

Study Suggests Benefit for Beta Blockers During Noncardiac Surgery

Larry Husten, PHD

The use of perioperative beta-blockade for noncardiac surgery has been declining as a result of the controversial POISE study, which turned up evidence for harm associated with extended-release metoprolol in this setting. Now a large new observational study published in JAMA offers a contrary perspective by suggesting that perioperative beta-blockade may be beneficial in low- […]

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