October 8th, 2012
Selections from Richard Lehman’s Literature Review: October 8th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include beta-blockers and the lack of a cardioprotective effect for certain patients; intra-aortic balloon support for MI with cardiogenic shock; prasugrel vs. clopidogrel for acute coronary syndromes without revascularization; CRP, fibrinogen, and CVD prediction; and a comparison of thrombectomy devices for acute ischemic stroke.
December 8th, 2010
The Spin on the Impella Device: PROTECTing Whom?
L. David Hillis, MD and Richard A. Lange, MD, MBA
The PROTECT II study — a prospective, multicenter, randomized, controlled comparison of the Impella cardiac assist device (produced by Abiomed) and the intra-aortic balloon pump (IABP) in patients requiring hemodynamic support during nonemergent, high risk PCI — was stopped early based on a futility determination regarding the primary endpoint at the time of planned interim analysis. What’s […]
December 8th, 2010
PROTECT II Study of Impella Stopped Early for Futility
Larry Husten, PHD
The PROTECT II study has been stopped early. The trial had been comparing the Impella circulatory support device to the intra-aortic balloon in high-risk PCI patients. The trial was terminated after an interim analysis by the Data and Safety Monitoring Board, which reached a “futility determination… regarding the primary end-point,” according to a press release […]
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