June 24th, 2011
FDA Recommends More-Conservative Dosing of ESAs
Larry Husten, PHD
The FDA today said that it was recommending more-conservative dosing of ESAs (erythropoiesis-stimulating agents) in patients with chronic kidney disease (CKD). The possible beneficial effects of the drugs to decrease the need for transfusions in CKD patients should be weighed against the increased risk for cardiovascular events, the FDA said. ESA therapy should be given at […]
May 10th, 2011
Trial REVEALs No Benefit and Some Concerns with Erythropoietin After Primary PCI
Larry Husten, PHD
Erythropoietin alfa failed to reduce infarct size and was associated with more cardiovascular events when given after successful PCI in STEMI patients, according to results from the REVEAL (Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction) trial published in JAMA. In the trial, which included a dose-escalation safety phase and a […]
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