CardioExchange Archive

September 15th, 2014

Selections from Richard Lehman’s Literature Review: September 15th

Richard Lehman, BM, BCh, MRCGP

This week’s topics include prehospital ticagrelor in STEMI, ivabradine in stable CAD without clinical HF, FFR-guided PCI for stable CAD, and more.

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May 13th, 2014

A Second Darapladib Phase 3 Trial Misses Its Endpoint

Larry Husten, PHD

GSK said today that a large phase 3 trial of a once highly promising drug had failed to meet its primary endpoint. Last year the company announced that another phase 3 trial with the same drug had failed. GSK said it would “further analyse the data and better understand the findings” but that, for now at least, […]

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May 8th, 2014

Selections from Richard Lehman’s Literature Review: May 8th

Richard Lehman, BM, BCh, MRCGP

This week’s topics include darapladib for preventing ischemic events in stable CHD, the DAMASCENE analysis, a review of John Brush’s new book, and more.

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November 12th, 2013

Promising GSK Heart Drug Misses Primary Endpoint in 15,000-Patient Trial

Larry Husten, PHD

GlaxoSmithKline announced today that the first of two pivotal phase 3 trials with a new drug, darapladib, had failed to meet its primary endpoint. Full results of the trial will be presented at a scientific meeting. The STABILITY trial (STabilisation of Atherosclerotic plaque By Initiation of darapLadIb TherapY) tested the effect of darapladib, an investigational Lp-PLA2 inhibitor, in more than […]

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