March 14th, 2012
The $800 Million Gamble: Jumping Aboard or Jumping the Gun?
Richard A. Lange, MD, MBA and L. David Hillis, MD
In the CLOSURE I trial (Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack Due to a Presumed Paradoxical Embolism through a Patent Foramen Ovale), 909 patients with a PFO who had a stroke or a transient ischemic attack (TIA) of unclear etiology were randomly assigned to device […]
November 15th, 2010
Let’s Bring CLOSURE to This Debate About PFO Treatment
Richard A. Lange, MD, MBA
In this blog, Rick Lange tells us how he would answer FAQs about PFO closure to prevent stroke. The controversy: Based on retrospective and nonrandomized studies, many physicians are convinced that percutaneous patent foramen ovale closure can reduce rates of cryptogenic stroke and transient ischemic attack. Although PFO closure devices are approved for stroke prevention in Europe […]
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