Anthony L Komaroff, MD

All posts by Anthony L Komaroff, MD

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July 31st, 2014

What Does CRISPR’s Success Mean for Cholesterol Control?

CRISPR is a new technique for inactivating or editing specific genes. Developed in microorganisms, it also works in mammalian cells, including in vitro human cells and monkey embryos. About 10 years ago, a gene was identified that is critical to production of the LDL cholesterol receptor (LDL-R): PCSK9. Naturally occurring human mutations that enhance the effect […]