June 5th, 2012
Troponin T Test Helps Assess Mortality Risk Following Noncardiac Surgery
A new study in JAMA finds that postoperative troponin T (TnT) tests can independently improve 30-day-mortality risk assessment among patients who have undergone noncardiac surgery.
The VISION (Vascular Events in Noncardiac Surgery Patients Cohort Evaluation) study investigators evaluated the prognostic power of postoperative fourth-generation TnT testing in 15,133 patients. Overall mortality at 30 days was 1.9%.
Some 11.6% of patients had peak TnT values greater than 0.02 ng/mL. These patients had an increased risk for death at 30 days:
- TnT <0.01 ng/mL (reference group): 1% mortality at 30 days
- TnT 0.02 ng/mL: 4.0%, adjusted hazard ratio 2.41 (1.33-3.77)
- TnT 0.03-0.29 ng/mL: 9.3%, HR 5.00 (3.72-6.76)
- TnT >0.30 ng/mL: 16.9%, HR 10.48 (6.25-16.62)