August 1st, 2011
Going Beyond COURAGE: NHLBI Funds the ISCHEMIA Study
The NHLBI has awarded an $84 million grant to fund the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA). The trial will randomize 8,000 patients with stable ischemic heart disease and moderate-to-severe ischemia. Two different treatment strategies will be compared:
- An invasive strategy, consisting of early routine cardiac catheterization followed by revascularization plus optimal medical therapy (OMT) and lifestyle changes.
- A conservative strategy of OMT and lifestyle changes in which invasive procedures will be performed only after failure of OMT.
In addition, ISCHEMIA will assess whether the invasive strategy is better able to improve angina-related quality of life.
NYU’s Judith Hochman is the study chair.