November 4th, 2012
ASPIRE: Aspirin an Attractive Alternative After First VTE
Larry Husten, PHD
It is unclear what the best approach is for the long-term treatment of people who have had a first unprovoked episode of venous thromboembolism (VTE). Although warfarin is effective at preventing a recurrence, it is inconvenient and raises the risk for bleeding. Newer anticoagulants have not been tested or approved for this population. The ASPIRE (Aspirin […]
June 26th, 2012
Aspirin Reduces Risk for Recurrent VTE
John Ryan, MD and ceciliabecattini690
John Ryan interviews Cecelia Beccatini about her new study that found that aspirin treatment in patients with first-time unprovoked VTE resulted in a significant reduction in VTE but did not increase the risk for bleeding.
May 29th, 2012
Selections from Richard Lehman’s Literature Review: Week of May 28th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include treating obstructive sleep apnea, using aspirin for VTE, and prothrombotics.
May 24th, 2012
Aspirin Found to Prevent Recurrent Venous Thromboembolism
Larry Husten, PHD
Aspirin can help prevent the recurrence of venous thromboembolism (VTE) after discontinuation of anticoagulation therapy, according to results of the WARFASA (the Warfarin and Aspirin) study published in the New England Journal of Medicine. Following 6 to 18 months of oral anticoagulation, 403 patients with first-time unprovoked VTE were randomized to aspirin (100 mg daily) or placebo for 2 […]
March 8th, 2012
The Psychological Impact of DVT and PE
Beth Waldron, MA
The evaluation of the care and outcome of patients with venous thromboembolism is often focused on the visible short-term effects of a clot, such as: Has the acute clotting episode resolved? Are chronic pain, swelling, or other post-thrombotic issues well managed? Has there been any bleeding associated with anticoagulation? Has there been a VTE recurrence? […]
December 28th, 2011
No Mortality Benefit of Low-Molecular-Weight Heparin in Acutely Ill Patients
Larry Husten, PHD
Although venous thromboembolism (VTE) is a serious problem for acutely ill patients in the hospital, a new study published in the New England Journal of Medicine failed to find any improvement in mortality associated with thromboprophylaxis. Ajay Kakkar and the LIFENOX investigators randomized 8307 acutely ill patients to receive enoxaparin or placebo for 10 days. All patients wore elastic […]
March 22nd, 2011
AHA Releases New Recommendations for Management of Acute VTE
Larry Husten, PHD
The AHA is offering new guidance for the management of patients with pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension. The scientific statement is published online in Circulation. In addition to advice about anticoagulant therapy, the statement offers extensive recommendations about the appropriate use of fibrinolytic agents, catheter-based and surgical interventions, and […]
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