CardioExchange Archive

July 16th, 2012

Does PPI + DAPT = MI?

Richard A. Lange, MD, MBA and L. David Hillis, MD

Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is the standard of care for prevention of coronary stent thrombosis. Unfortunately, DAPT is associated with an increased risk for gastrointestinal hemorrhage. Although this risk can be reduced with the concomitant administration of a proton pump inhibitor (PPI), initial observational studies suggested that PPI use with DAPT is associated with an increased […]

---

October 25th, 2011

Genetic and Clinical Factors Linked to Stent Thrombosis

Larry Husten, PHD

French researchers have identified several genetic and clinical factors independently tied to early stent thrombosis. Writing in the Journal of the American Medical Association, Guillaume Cayla and colleagues report on their case-control study comparing 123 patients with definite early stent thrombosis with 246 matched controls without stent thrombosis. The researchers found three genes with variants that […]

---

March 28th, 2011

Updated Unstable Angina/Non-STEMI Guidelines Released by ACC & AHA

Larry Husten, PHD

The AHA and ACC have released a focused update of the 2007 guidelines for the management of unstable angina and non-STEMI. The guidelines incorporate new information from recent clinical trials, and deal with controversial topics such as the choice of antiplatelet agents, the use of platelet-function and genetic tests with antiplatelet agents, and the timing […]

---

November 9th, 2010

Statement from AHA, ACC, and ACG Reaffirms Use of PPIs with Antiplatelet Therapy

Larry Husten, PHD

Despite recent warnings by the FDA, an expert consensus document released jointly by the AHA, the ACC, and the American College of Gastroenterology states that it is acceptable to use proton pump inhibitors (PPIs) with thienopyridines like clopidogrel in patients at high risk for upper GI bleeds. The statement does not recommend routine use of […]

---

September 20th, 2010

Encouraging Observational Data on Clopidogrel and PPIs

Larry Husten, PHD

Compared with a PPI alone, the combination of clopidogrel and a PPI does not increase risk for cardiovascular events, according to a large observational study from Denmark published in the Annals of Internal Medicine. Mette Charlot and colleagues analyzed data from 56,406 Danish patients discharged after a first MI and found no difference between the […]

---