October 6th, 2010
Study Finds No Evidence for Clopidogrel-Omeprazole Interaction
Sanjay Kaul, MD and Larry Husten, PHD
A large clinical trial has found no evidence that omeprazole interferes with the cardiovascular efficacy of clopidogrel. COGENT (Clopidogrel and the Optimization of Gastrointestinal Events Trial) randomized 3873 patients eligible for dual antiplatelet therapy to receive aspirin, clopidogrel, and either omeprazole or placebo. The COGENT investigators had planned to enroll 5000 patients, but the trial […]
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