September 5th, 2014
Perspectives on PARADIGM-HF
CardioExchange Editors, Staff
The Editors present a distillation of reader comments on a popular post.
August 30th, 2014
Will There Be a PARADIGM Shift in Treatment of Heart Failure?
John McMurray, MbChB MD and Milton Packer, MD
John J.V. McMurray and Milton Packer, the two lead authors of the PARADIGM-HF trial, discuss the randomized comparison of angiotensin–neprilysin inhibition with the ACE inhibitor enalapril.
March 31st, 2014
Novartis Trial Was Stopped Early Because of a Significant Drop in Cardiovascular Mortality
Larry Husten, PHD
The largest-ever trial in heart failure was stopped early because of a highly statistically significant reduction in cardiovascular mortality, according to one of the trial’s two primary investigators. Earlier today I reported that the PARADIGM-HF trial testing LCZ696, a novel, first-in-class Angiotensin Receptor Neprilysin Inhibitor (ARNI), had been stopped early because the trial had demonstrated a significant reduction in the combined […]
March 31st, 2014
Early Success for Novel Novartis Heart Failure Drug
Larry Husten, PHD
A large clinical trial testing a novel compound from Novartis for chronic heart failure has been stopped early for efficacy. In a press release Novartis said the Data Monitoring Committee had recommended early closure of the PARADIGM-HF trial because the trial had demonstrated a significant reduction in the combined primary endpoint of cardiovascular death and heart failure hospitalization. PARADIGM-HF randomized patients with heart failure […]
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