December 27th, 2011
Clopidogrel Testing Comes Under Fire
Larry Husten, PHD
The phenomenon of clopidogrel resistance has been much discussed, but no consensus has emerged about the best, or any, response to the problem. Now a review published in JAMA finds no clinically relevant relationship between the CYP2C19 genotype and cardiovascular events. Michael Holmes and colleagues performed a meta-analysis of 32 studies involving CYP 2C19 genotyping and more than […]
October 27th, 2010
Meta-Analysis Examines Risk Associated with CYP2C19 Genotypes
Larry Husten, PHD
There has been widespread debate and disagreement over the clinical significance of people with reduced function CYP2C19 genotypes who take clopidogrel. In an effort to shed light on the topic, Jessica Mega and colleagues analyzed data from 9685 patients enrolled in nine clinical trials. Some 26% of patients had 1 reduced-function allele, and 2% had […]
August 31st, 2010
The CURE for Clopidogrel Genotyping?
Guillaume Pare, MD, MSc
CardioExchange welcomes Guillaume Paré to discuss his team’s work on the utility of clopidogrel genotyping. The researchers genotyped for CYP2C19 alleles associated with loss-of-function or gain-of-function of clopidogrel in some 5,000 patients with ACS or A-fib from two large randomized trials. In both studies, clopidogrel had similar efficacy over placebo regardless of whether patients had […]
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