CardioExchange Archive

November 13th, 2012

Expert Consensus Document Offers Advice on Troponin Tests

Larry Husten, PHD

A newly published document provides practical advice on the use of the popular and potent troponin tests. The Expert Consensus Document on Practical Clinical Considerations in the Interpretation of Troponin Elevations was developed by the American College of Cardiology Foundation in collaboration with several other societies to help address the many complex issues raised by the introduction […]

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September 24th, 2012

‘Dramatic’ Increase in Bleeding Accompanies Addition of Oral Anticoagulant Therapy in ACS

Larry Husten, PHD

The newer oral anticoagulants may help reduce ischemic events after an acute coronary syndrome (ACS), but only at the cost of a “dramatic” increase in bleeding complications, according to a new meta-analysis published in the Archives of Internal Medicine. Hungarian researchers performed a systematic review and meta-analysis of seven trials in which 31,286 ACS patients were […]

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August 26th, 2012

Prasugrel vs. Clopidogrel in ACS: The TRILOGY Take

John Ryan, MD

TRILOGY author Matt Roe answers CardioExchange’s questions about his team’s study of clopidogrel vs. prasugrel in ACS.

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August 26th, 2012

TRILOGY at ESC: No Advantage for Prasugrel Over Clopidogrel in Medical ACS Patients

Larry Husten, PHD

The newer antiplatelet agent prasugrel was no better than the old standby clopidogrel for treating patients with acute coronary syndrome (ACS) who are not undergoing revascularization. The results of the TRILOGY ACS (Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes) trial were presented by Matt Roe at the European Society of […]

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August 2nd, 2012

Survival Better with a Radial (vs. Femoral) PCI Approach: Sleight of Hand?

Richard A. Lange, MD, MBA and L. David Hillis, MD

Is there a plausible explanation for why the radial approach to PCI would yield better survival than the femoral approach in patients with ST-segment ACS?

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May 23rd, 2012

FDA Advisory Committee Recommends Against ACS Indication for Rivaroxaban

Larry Husten, PHD

The FDA’s Cardiovascular and Renal Drugs Advisory Committee voted today against adding an indication for acute coronary syndromes (ACS) to the label of the anticoagulant rivaroxaban (Xarelto). The vote was 6 to 4 against approval, with 1 abstention. The advisory panel spent most of the day trying to reconcile diametrically opposed views of the pivotal ATLAS ACS 2-TIMI […]

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May 21st, 2012

Rivaroxaban for ACS Gets Positive FDA Review, but Questions About ATLAS Trial Conduct Persist

Larry Husten, PHD

The FDA will offer generally positive – but also highly mixed – advice to the FDA’s Cardiovascular and Renal Drugs Advisory Committee when it meets on Wednesday to consider the supplemental new drug application for rivaroxaban (Xarelto, Johnson & Johnson) for use in patients with acute coronary syndrome (ACS) already taking dual antiplatelet therapy. The FDA posted the briefing […]

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May 11th, 2012

A ‘Brilinta’ Theory on Why Ticagrelor Doesn’t Work as Well in the U.S.

Harry Peled, md

Harry Peled wonders whether intermediate-dose aspirin may simply be so effective that it obviates the need for a P2Y12-receptor antagonist.

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February 28th, 2012

FDA Grants Priority Review to Rivaroxaban (Xarelto) for ACS Patients

Larry Husten, PHD

The FDA has granted a priority review for the supplemental new drug application (sNDA) for rivaroxaban (Xarelto) in combination with standard therapy to reduce the risk for cardiovascular events in acute coronary syndrome (ACS) patients. The news was announced by Bayer and Johnson & Johnson. The FDA will now be required to respond within 6 months, instead of […]

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January 12th, 2012

Selections from Richard Lehman’s Weekly Review: Week of January 9th

Richard Lehman, BM, BCh, MRCGP

This week’s topics: bariatric surgery, length of stay and MI, secondary prevention after ACS, and vorapaxar

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