Posts

January 27th, 2011

HPS Results Suggest Baseline CRP Doesn’t Predict Statin Efficacy

Analysis of data from the Heart Protection Study (HPS) indicates that a CRP measurement obtained at baseline does not predict the effect of statin therapy. In a paper published online in the Lancet, the HPS Collaborative Group report the results of the more than 20,000-patient HPS study based on CRP category at baseline. As previously reported, in the overall trial major vascular events were reduced with statins by 24% when compared to placebo.

In the current report, the investigators report no significant differences in the relative effect of statins among 6 groups determined by CRP baseline levels. Even in patients with the lowest CRP concentrations, statin treatment resulted in a 29% reduction in events. The same pattern was true for LDL levels and for the combination of LDL and CRP levels: a 27% reduction in risk was observed in patients with both low LDL and low CRP levels at baseline.

The HPS investigators conclude: “The results do not lend support to the suggestion that the beneficial effects of statin therapy are affected by baseline CRP concentration or, more generally, by inflammation status.”

In an accompanying comment, Jean-Pierre Després notes that although CRP and LDL did not predict the relative efficacy of statins, they were both associated with the absolute risk of patients in HPS.

Paul M. Ridker, a leading researcher on the value of C-reactive protein (CRP) concentration as a prognostic marker of cardiovascular risk, responds to this latest study in his new Voices blog: Does CRP Level Modify the Benefit of Statins? Paul Ridker Reacts to New Data.

January 27th, 2011

Shockable Arrhythmias Less Frequent in the Home

Cardiac arrest with a shockable arrhythmia (VF or pulseless VT) is less likely to occur at home than in public, according to a new study published in the New England Journal of Medicine. Myron Weisfeldt and investigators from the Resuscitation Outcomes Consortium (ROC) Investigators evaluated nearly 13,000 out-of-hospital cardiac arrests and found that shockable arrhythmias occurred more than twice as frequently in public than in the home. When AEDs were used, the rate of survival to hospital discharge was 34% for arrests that happened in public compared to only 12% for arrests that happened at home.

The authors conclude that their finding “adds strength to the argument for putting AEDs in public locations” and suggests that “a treatment strategy that emphasizes prompt, bystander-delivered CPR of high quality (e.g., with the assistance of a dispatcher) should be as effective in saving lives as the widespread deployment of AEDs in homes.”

In an accompanying editorial, Gust Bardy suggests the difference between home and public cardiac arrests may be more apparent than real, since the study finding might “be explained simply as a matter of response speed.” Although, he writes, “no grounds exist to broadly promote publicly financed home AEDs… this policy assessment should not dissuade persons from purchasing their own AEDs” and “other than the personal expense, there is no known downside to such a purchase.”

Bardy disagrees with the ROC investigators’ support for CPR, and argues that it is “time to reassess the value of CPR, not dismiss definitive therapy with defibrillation.” A clinical trial would allow us to “stop spending hundreds of millions of dollars and millions of hours of ‘training’ on a ‘therapy’ that makes people feel good but does little else. The cold, hard facts of the persistently low survival rate with the already existing national embrace of CPR make it hard to do worse.”

January 27th, 2011

EPI/NPAM 2011

Nutrition, Physical Activity and Metabolism and Cardiovascular Disease Epidemiology and Prevention 2011 Scientific Sessions

Atlanta, GA

January 27th, 2011

End of an Era: Eugene Braunwald Steps Down, Marc Sabatine Assumes Chair of TIMI Group

Marc Sabatine has replaced Eugene Braunwald as the chairman of the TIMI study group. Braunwald, who has been the dominant figure in cardiology for many decades, is 81. Sabatine was appointed Vice Chairman of the TIMI group last summer and he assumed the chairman’s role on January 1.

Braunwald is not retiring and will continue to serve as chairman for individual trials already underway. Sabatine enjoys strong support within the TIMI group and within Brigham and Women’s Hospital. Although no public announcement of the change has been made, and Braunwald is still listed as the TIMI chairman on the TIMI website, the change has been widely known at the Brigham for some time. Industry sponsors of TIMI trials have also been informed of the change in leadership.

TIMI member Chris Cannon commented on Sabatine’s new role: “We are all thrilled to have one of cardiology’s best and brightest to lead the TIMI Study Group. Marc is a world-class clinical trialist who also does cutting-edge pharmacogenomics and metabolomics work. He is a superb clinician and has been recognized several times as outstanding teacher of the year here at Harvard. As our trials have grown in size and number, we are all delighted to have Marc lead our Academic Research Organization into the future.”

January 26th, 2011

Study Finds Declining Stroke Rate After CABG

Despite the increasing complexity of cases, the risk of stroke after CABG may be declining, according to a new study published in JAMA. Khaldoun Tarakji and colleagues prospectively studied more than 45,000 patients who underwent CABG at the Cleveland Clinic from 1982 through 2009.

The overall stroke rate was 1.6%. The stroke rate was highest in 1988 (2.6%) and then declined by 4.69% per year. More strokes occurred after surgery than during surgery. Off-pump CABG and on-pump beating-heart CABG were associated with the lowest risk of stroke, on-pump arrested-heart CABG was associated with a slightly higher risk, while on-pump CABG with hypothermic systemic circulatory arrest had the highest risk.

January 25th, 2011

AHA Scientific Sessions 2011

American Heart Association Scientific Sessions 2011

Orlando, FL

January 25th, 2011

TCT 2011

Transcatheter Cardiovascular Therapeutics 2011

San Francisco, CA

January 25th, 2011

ESC Congress 2011

European Society of Cardiology Congress 2011

Paris, France

January 25th, 2011

ACC.11

ACC.11

New Orleans, LA

60th Annual Scientific Session and Expo

January 25th, 2011

Inappropriate ICD Shocks Linked to Increased Mortality

A large, single-center observational study has found a link between inappropriate ICD shocks and mortality. In a report published in JACC, Johannes van Rees and colleagues from the Netherlands followed 1,544 patients who received an ICD from 1996 to 2006.

Thirteen percent of patients had at least one inappropriate shock over 41 months of followup. Age below 70 and the presence of atrial fibrillation were independent predictors of inappropriate shocks. The investigators failed to find any evidence that the incidence of inappropriate shocks decreased as a result of improvements to ICDs over time.

In what the authors termed their “most important finding”, patients with at least one inappropriate shock had a 60% increase in the risk of death.The risk of death increased with subsequent additional inappropriate shocks; patients with 5 inappropriate shocks had a more than three-fold increase in risk.

“It is not acceptable that so many patients suffer from inappropriate shocks,” said Martin Schalij, senior author of the study, in an ACC press release. “ICD therapy must be improved, through both patient-tailored programming of the devices and the development of superior algorithms to allow ICDs to better determine false alarms, such as supraventricular arrhythmias.”