CardioExchange Archive

CardioExchange, an NEJM practice community for medical professionals dedicated to improving cardiac patient care, was active from 2009 to 2015. CardioExchange fostered discussion between clinicians from across the globe.

November 6th, 2014

Agent Could Potentially Reverse Anticoagulation Associated with Edoxaban

PER977 — a cation that binds to all of the new oral anticoagulants and heparin — may help reverse the anticoagulant effects of edoxaban, according to results of an industry-conducted trial published in the New England Journal of Medicine. Edoxaban, an oral factor Xa inhibitor, was recently recommended for approval by an FDA advisory panel.

Researchers studied whole-blood clotting time in 80 healthy people who were given PER977 following a dose of edoxaban. After receiving edoxaban, participants’ mean whole-blood clotting time rose by 37%. But after administration of PER977, whole-blood clotting time fell to within 10% of the baseline value in 10 minutes or less, and the effect lasted for 24 hours. Participants receiving placebo took 12 to 15 hours to reach that level.

The researchers did not observe signs of procoagulant activity with PER977, and adverse events were minimal.

This compound may also be effective and will likely be tested in the other new oral anticoagulants, as well as unfractionated heparin and low-molecular-weight heparins.

Categories: Anticoagulation
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3 Responses to “Agent Could Potentially Reverse Anticoagulation Associated with Edoxaban”

  1. H. Joel Gorfinkel, MD says:
    November 6, 2014 at 7:24 pm

    Will it also work on dabigatran?

  2. David Powell , MD, FACC says:
    November 6, 2014 at 10:33 pm

    For some reason they say it does work for dabigatran. There is a specific Fab fragment under intense investigation for dabigatran reversal as well as a Xa decoy agent, judged quite promising for the Xa inhibitors, including LMWH. The reversal field is booming.

  3. Dr Kuchya, MBBS MD DNB says:
    November 7, 2014 at 12:00 pm

    Great leap forward to ensure safer anticoagulation.