November 17th, 2010

Negative Trials, Positive Impact

Several Cardiology Fellows who are attending this week’s AHA meeting are blogging together on CardioExchange. The Fellows include Susan Cheng, Madhavi Reddy, John Ryan, and Amit Shah. Check back often to learn about the biggest buzz in Chicago this week — whether it’s a poster, a presentation, or the word in the hallways. You can read the preceding post here.

After the sessions today, I grabbed a cup of coffee with a few friends before they flew out of town. After going through many of the results of the studies presented at the meeting, we recognized a common theme: there were a lot of negative studies. PFO closure is no different from medical therapy (CLOSURE 1), there is no benefit of clopidogrel dosing based on platelet function testing (GRAVITAS), Omega 3 is not effective for A Fib, and N-acetylcysteine NAC) makes “absolutely no difference” in contrast-induced nephropathy (ACT). However, in this setting, these negative (or, perhaps more appropriately, “neutral”) studies are likely to have a substantial effect on patient care. Or, at least one would expect that they should. Each of the studies was well designed and well executed. Will physicians now feel comfortable with not closing PFOs in patients with cryptogenic stroke? Defensive medicine has long generated concern among physicians and has been shown to significantly influence practice. So, over the next few months, it will be interesting to see whether these studies are sufficiently powerful to reassure physicians not to give NAC before coronary angiogram in patients with mild renal insufficiency. Because, after, all NAC does not have any adverse side effects. One of my colleagues commented that this is because “it also has no positive effects…you know what else has no side effects? Placebo.” What are people’s thoughts?

After the excitement surrounding my inaugural talk yesterday, today was more relaxing. The Chicago-land AHA had invited 187 high school students to the scientific sessions, and 11 fellows from the city volunteered to show them around the exhibition hall and talk to them about careers in science. I had a group of twelve students from north of the city. I did not know exactly how to tell them about the things we do. I was going to try and identify with them by talking about iCarly and Justin Bieber, but I suspected that it might not go over very well. So, instead I decided to give them an inspiring talk about all the great things that have been discovered and presented at AHA, such as Paul Dudley White, Goldstein and Brown, and Mason Sones. It was a lot of fun trying to engage these high school seniors in cardiology and telling them tales to inspire them. However, at the same time it was also a challenge to explain our everyday issues, such as MIs, arrhythmias, or heart failure, and break them down to a basic level. What do people normally do to try and inspire high schoolers to consider a career in medicine? Or would you even recommend a career in medicine, with the current changes that we are going through? I told them about the 8 years of training that follow medical school, and their eyes opened wide as they considered that it would take them almost twice as many years as the age they are right now to become cardiologists. I tried to put it in context by saying that master chef apprenticeships are just as long, hoping that they were Iron Chef fans. Needless to say, they were not. Nonetheless, I hope that I still made a positive impression on these students.

Thanks to all who have commented on our blogs over the last few days. This has been a fun venture, and I hope you have enjoyed it as much as we have.

2 Responses to “Negative Trials, Positive Impact”

  1. Saurav Chatterjee, MD says:

    Let the games begin……Today is Dec 1st-technically the first day of fellowship applications for cardiology….I have made my choices-and sent in my application.How to maximise my chances for getting into a desired program-mentors/fellows/co-applicants-plz share your views and lets enlighten each other…….

  2. Saurav Chatterjee, MD says:

    As per my Cardiology mentors-I chose about 60% of programs where I knew my seniors had matched or other candidates with similar creds….and then I chose about 20% each of programs which I would be lucky to be in(and hopefully vice versa….hahaha!!)and about 20% where probably I would be less happy than at my own home insituition(where I am training currently)……….