April 7th, 2010

• CIMT in Risk Assessment
• Survival After CABG — It’s Not Race or Sex, It’s Being Poor

CIMT in Risk Assessment: When added to traditional risk factors, CIMT (carotid intima-media thickness) and the presence or absence of plaque improve risk prediction, according to a paper from the ARIC (Atherosclerosis Risk in Communities) Study in the Journal of the American College of Cardiology. Vijay Nambi and colleagues report that they were able to reclassify nearly a quarter of more than 13,000 subjects with the added information from CIMT and plaque. The authors concluded that “ultrasound-based risk stratification strategies should be tested in clinical trials to evaluate whether improved prevention of cardiovascular events is possible.”

In an accompanying editorial comment, James Stein and Heather Johnson write that the study “closes the discussion about the incremental value of carotid ultrasound for CHD risk prediction in patients at intermediate risk, thus opening the door for outcomes research studies that are required to determine if atherosclerosis imaging truly is as helpful as its proponents believe.”

Survival After CABG — It’s Not Race or Sex, It’s Being Poor: Socioeconomic position (SEP) is far more important than race or sex in affecting long-term survival after CABG, according to a new report in Circulation: Cardiovascular Quality and Outcomes. Colleen Koch and colleagues studied 23,330 CABG patients and found that lower SEP was associated with a worse outcome. Race and sex were no longer significant factors after adjustment for SEP.  “We were surprised that consistently and pervasively, through every way of looking at the data, it turns out this isn’t about skin color or gender. It’s about being poor,” said Koch, in a press release issued by the American Heart Association.

One Response to “• CIMT in Risk Assessment
• Survival After CABG — It’s Not Race or Sex, It’s Being Poor”

  1. Carotid IMT is great for stroke but only OK for MI risk stratification as it does not equal coronary calcium imaging

    Carotid IMT reclassified 25% of intermediate risk subjects in this study, in a paper presented at ACC 2009 in Orlando demonstrated that 76% of intermediate risk subjects were reclassified as either low risk (62%) or high risk (14%) based on EBT coronary calcium imaging.

    MESA further demonstrated that Coronary Calcium Imaging was 5 times more predictive of MI risk than Carotid IMT after considering conventional risk factors.

    The best idea is to do both, coronary calcium to optimize MI risk stratification and carotid ultrasound to optimize stroke risk stratification.

    Competing Interests: I have an ownership interest in a facility that can do carotid ultrasounds imaging and EBT calcium imaging.