January 12th, 2010
Tuesday January 12 Roundup: Statin Adherence; FDA Panel Grills Nebivolol; CETP, CRP and APOE in dementia
Larry Husten, PHD
You can save twice as many lives by increasing adherence to already-prescribed statins than by expanding the pool of people eligible for statins, according to estimates by A Shroufi and JW Powles in the Journal of Epidemiology and Community Health.
The FDA Cardiovascular and Renal Drugs Advisory Committee unanimously recommended that the FDA turn down a heart failure indication for nebivolol (Bystolic, Forest Laboratories). Stories in Cardiology Today, Heartwire, MedPage Today.
A preliminary report in JAMA found that people who had one CETP variant were less likely to experience memory decline and had a lower risk for developing dementia or Alzheimer’s disease.
A study in the Archives of Neurology by James Noble and colleagues found that high CRP may be a marker of memory and visuospatial impairment. Subjects with elevated CRP and at least one APOE ε4 allele had the highest risk of memory loss.
Another study in the Archives of Neurology found that prior to the development of Alzheimer’s disease, carriers of APOE ε4 have reduced cerebral blood flow compared to noncarriers.
