August 8th, 2012
Selections from Richard Lehman’s Literature Review: August 8th
Richard Lehman, BM, BCh, MRCGP
This week’s topics include heart failure and depression, endoscopic vs. open vein-graft harvest for CABG, linagliptin vs. glimepiride in those with type-2 diabetes, weight gain with smoking cessation, ACE inhibitors and pneumonia risk, and the effect of speech therapy after stroke.
June 29th, 2012
Linagliptin and Glimepiride Compared in Type 2 Diabetes
Larry Husten, PHD
Sulfonylureas are often added to metformin to improve glycemic control, but at the known risk of increasing hypoglycemia and weight gain. In a report published in the Lancet, more than 1,500 patients with type 2 diabetes taking metformin were randomized to the addition of either linagliptin, a dipeptidyl peptidase-4 inhibitor, or glimepiride, a sulfonylurea. After two years, the trial […]
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