CardioExchange Archive

March 20th, 2014

Pulmonary Embolism in a Patient with Acute Decompensated Systolic Heart Failure

Ian Neeland, MD and James Fang, MD

Ian Neeland presents our latest case: A 42-year-old man with heart failure is found to have a large pulmonary embolus. Tell us how you’d manage his treatment.

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September 30th, 2013

Nesiritide Does Not Increase Diuresis in ADHF Patients

Stephen Gottlieb, MD

Stephen Gottlieb discusses his research group’s analysis of ASCEND-HF data, which shows that nesiritide does not increase urine output in patients with ADHF.

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July 1st, 2013

Selections from Richard Lehman’s Literature Review: July 1st

Richard Lehman, BM, BCh, MRCGP

This week’s topics include studies on aggressive fluid and sodium restriction in acute decompensated HF, the yield of routine cardiac testing in an ED-based chest pain unit, and more.

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June 27th, 2013

Novel Heart Failure Drug from Novartis Gains ‘Breakthrough Therapy’ Designation from FDA

Larry Husten, PHD

Serelaxin, the novel therapy under development for the treatment of acute heart failure, has received a “breakthrough therapy” designation from the FDA, according to Novartis, the company developing the drug. The designation, the FDA explains, “is intended to expedite the development and review of drugs for serious or life-threatening conditions” and requires “preliminary clinical evidence that demonstrates the […]

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November 6th, 2012

Ultrafiltration Fails to Show Benefit in Acute Heart Failure

Larry Husten, PHD

Although ultrafiltration (UF) in recent years has become increasingly popular as an alternative to intravenous diuretics for patients with acute decompensated heart failure with acute cardiorenal syndrome (type 1), the first clinical trial to test its value shows that it is inferior to standard drug therapy. The results of CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart […]

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July 7th, 2011

ASCEND-HF: No Harm or Benefit with Nesiritide

Larry Husten, PHD

With the publication of the final results of the ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) trial in the New England Journal of Medicine, the once intense controversy over the use — or misuse — of the drug nesiritide in patients with acute decompensated heart failure has finally been resolved. […]

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