CardioExchange Archive

April 10th, 2013

Scientific Misconduct: From Darwin and Mendel to Poldermans and Matsubara

Larry Husten, PHD

Responding to recent episodes of scientific misconduct in cardiovascular research involving once prominent cardiovascular researchers, the editor of the European Heart Journal, Thomas Lüscher, has written an editorial discussing the significance of the new cases and placing them in a historical context that includes allegations of scientific misconduct by Mendel and Darwin, among many others. Lüscher writes that scientific misdoncuct […]

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August 1st, 2014

Noncardiac Surgery Guidelines Updated

Larry Husten, PHD

The reliability of current guidelines regarding perioperative evaluation and treatment of people undergoing noncardiac surgery has been seriously questioned because of a scandal discrediting Don Poldermans, a Dutch researcher widely published in the field. To address the current uncertainty, U.S. and European medical societies today released updated versions of these guidelines. The European guideline can be […]

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February 13th, 2014

Perioperative Beta-Blockade: Between a Rock and a Hard Place

Prashant Vaishnava, MD, Vineet Chopra, MD, MSc and Kim Allen Eagle, MD

In light of the continuing controversy over the Don Poldermans research misconduct case, Prashant Vaishnava, Vineet Chopra, and Kim Eagle discuss the use of perioperative beta-blockade.

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August 20th, 2013

A Pathway to Preventing Research Fraud

Harlan M. Krumholz, MD, SM

Is the road to fraud-free research paved with publicly accessible raw data?

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July 31st, 2013

European Heart Guidelines Based on Disgraced Research May Have Caused Thousands of Deaths

Larry Husten, PHD

Despite a 2-year-old scandal discrediting key evidence, current guidelines relying on this evidence have not been revised. As a result of physicians following these guidelines, some researchers say, it is possible that thousands of patients may have died each year in the U.K. alone. It is unlikely that a true understanding of the damage will […]

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October 9th, 2012

Erasmus Medical Center Releases Final Report on Cardiovascular Research Scandal

Larry Husten, PHD

After an extensive investigation, a large medical center in the Netherlands has confirmed earlier charges of research misconduct against a prominent cardiovascular researcher. On Tuesday, Erasmus Medical Center in Rotterdam released a final report on the scientific integrity of trials conducted by Don Poldermans, a well-known and highly prolific Dutch cardiovascular researcher. The final report contains numerous […]

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November 21st, 2011

Prominent Dutch Cardiovascular Researcher Fired for Scientific Misconduct

Larry Husten, PHD

UPDATE (Posted Monday, November 21): Over the weekend more details emerged about this story. An executive summary of the report from the investigative committee at Erasmus MC, dated November 16, appeared on the Erasmus website. Here is a brief summary, based on help received from Google Translate, Babel Fish, and native Dutch speakers: As previously reported […]

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November 3rd, 2009

Does coronary revascularization make noncardiac surgery safer?

Richard A. Lange, MD, MBA

Does coronary revascularization make noncardiac surgery safer?  If so, when?   On the cardiology consult service today, we evaluated a man who needs a “low risk” gastrointestinal surgical procedure urgently.  He presented to hospital admission with a prolonged hypotensive episode associated with anterior ST depression and mildly elevated troponin levels and without chest pain. He had […]

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